ISTODAX
Used for Cancer
Are you tired of high medication costs? Our service offers unbeatable savings on your ISTODAX prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by Bristol-Myers Squibb
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ISTODAX key facts
What is ISTODAX?
ISTODAX is the brand name for romidepsin and is available as an injection for IV use.
What dosages is ISTODAX available in?
ISTODAX is available as a single-dose vial that contains 10 mg of romidepsin.
What is ISTODAX used for?
ISTODAX is a histone deacetylase (HDAC) inhibitor indicated for the treatment of
cutaneous T-cell lymphoma (CTCL) in adult patients who have received at least one prior
systemic therapy
How does ISTODAX work?
ISTODAX works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.
How do I take ISTODAX?
ISTODAX is dosed as follows:
14 mg/m2 administered intravenously over a 4-hour period on days 1, 8, and 15 of
a 28-day cycle. Repeat cycles every 28 days provided that the patient continues to
benefit from and tolerates the drug.
Discontinue or interrupt treatment (with or without dose reduction to 10 mg/m2) to
manage drug toxicity.
Reduce starting dose in patients with moderate and severe hepatic impairment.
Is it safe for me to take ISTODAX?
ISTODAX is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
ISTODAX Common Side Effects
Common side effects of ISTODAX:
- Nausea
- Fatigue
- Infections
- Vomiting
- Weight loss
- Heart rhythm changes
- Altered taste
- Constipation
ISTODAX Serious Side Effects
Serious side effects are rare with ISTODAX. Contact your doctor or seek medical help if you experience any of the following.
Low blood cell counts
Serious infections
Changes in your heartbeat
Tumor lysis syndrome
Effects of other drugs, drug classes and over-the-counter products on ISTODAX
The following medications may interact with ISTODAX:
- Carefully monitor prothrombin time (PT) and International Normalized Ratio (INR) in
- patients concurrently administered ISTODAX and warfarin or coumarin derivatives.
- Monitor for toxicities related to increased romidepsin exposure when co-administering
- romidepsin with strong CYP3A4 inhibitors.
- Avoid use with rifampin and strong CYP3A4 inducers.
Who makes ISTODAX?
Bristol-Myers Squibb
Is ISTODAX safe in pregnancy?
ISTODAX may harm your unborn baby.
Females who are able to become pregnant:
Your healthcare provider will perform a pregnancy test within 7 days before you start treatment with ISTODAX.
You should avoid becoming pregnant during treatment with ISTODAX and for 1 month after the last dose.
You should use effective birth control (contraception) during treatment with ISTODAX and for 1 month after your last dose.
ISTODAX may affect the way estrogen-containing birth control works. Talk to your healthcare provider for more information about other types of birth control to use during treatment with ISTODAX.
Tell your healthcare provider right away if you become pregnant or think you may be pregnant during
treatment with ISTODAX.
Males with a female sexual partner who can become pregnant:
ISTODAX can harm the unborn baby of your partner.
You should use a condom and avoid fathering a child during treatment with ISTODAX and for 1 month after treatment with ISTODAX. Talk to your healthcare provider if this is a concern for you.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ISTODAX prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ISTODAX prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ISTODAX savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ISTODAX savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ISTODAX | Canadian Prescription Savings* for ISTODAX | ISTODAX Drug Coupon* | ISTODAX Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ISTODAX?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ISTODAX | Canadian Prescription Savings* for ISTODAX | ISTODAX Drug Coupon* | ISTODAX Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ISTODAX savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ISTODAX drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ISTODAX, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ISTODAX prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ISTODAX is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ISTODAX for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ISTODAX prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ISTODAX prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ISTODAX
If you are having trouble paying for your ISTODAX medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ISTODAX you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ISTODAX is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ISTODAX
- If ISTODAX is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ISTODAX
If you are having trouble paying for your ISTODAX medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ISTODAX you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ISTODAX
- If ISTODAX is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ISTODAX
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ISTODAX treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ISTODAX you will need to meet the following criteria:
- You must be currently insured and have coverage for ISTODAX
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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You can lower the cost of your prescription medications using our various savings programs which include drug coupons, savings card and manufacturer-sponsored patient assistance programs.
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