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Hyrimoz is the brand name for adalimumab-adaz and is available as a subcutaneous injection.

Hyrimoz is available as a 40 mg/0.8 mL single-dose pre-filled glass syringe or 40 mg/0.8 mL single-dose pre-filled pen.

Hyrimoz is a tumor necrosis factor (TNF)-blocker used to treat:

• Rheumatoid arthritis (RA) – adults only
• Juvenile idiopathic arthritis (JIA) – people age 4 and older
• Psoriatic arthritis (PsA) – adults only
• Ankylosing spondylitis (AS) – adults only
• Crohn’s disease (CD) – adults only
• Ulcerative colitis (UC) – adults only
• Plaque psoriasis – adults only
• Hidradenitis suppurativa – adults only
• Uveitis – adults only

Hyrimoz tumor necrosis factor (TNF)-blocker. TNF is a protein in your body that plays a role in inflammation. By blocking TNF, Hyrimoz lowers inflammation in different parts of your body.

Hyrimoz is typically dosed as follows:

• Adults
• Rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: The typical starting dose is 40 mg injected under the skin every other week.
• Crohn’s disease and ulcerative colitis: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every other week on Day 29.
• Plaque psoriasis and uveitis: The typical dose is 80 mg injected under the skin on Day 1, followed by 40 mg every other week starting 1 week after the first dose.
• Hidradenitis suppurativa: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every week OR 80 mg every other week starting Day 29.
• Children
• Juvenile idiopathic arthritis: The dose will be based on your child’s body weight. Typically it will be injected under the skin once every other week.

Hyrimoz is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Hyrimoz:

• Injection site reaction
• Upper respiratory tract infection
• Headache
• Rash
• Sinus inflammation
• Accidental injury
• Nausea
• Urinary tract infection (UTI)

Serious side effects are rare with Hyrimoz. Contact your healthcare provider immediately if you experience any of the following:

• Serious infection: fever, cough, weight loss, muscle aches, dark urine, chills, vomiting
• Low blood cell counts: fever that doesn’t go away, easy bruising or bleeding, pale skin
• Severe allergic reaction: hives, rash, trouble breathing, swelling of your face, eyes, lips, or mouth
• Heart failure: shortness of breath, sudden weight gain, swelling in the legs, ankles, or feet, irregular heartbeat, tiredness
• Liver problems: feeling tired, vomiting, yellow skin or whites of the eyes, stomach pain

The following medications may interact with Hyrimoz:

• Abatacept
• Anakinra
• Live vaccines

Sandoz

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Adalimumab-Adaz