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Glimepiride is available as a 1 mg, 2 mg, and 4 mg tablet.

Glimepiride is a sulfonylurea indicated along with diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Glimepiride is a sulfonylurea. It works by attaching to certain pancreatic cells in your body that make insulin. When Glimepiride (Glimepiride) is attached, it tells your pancreas to release more insulin into the blood, which helps to lower blood sugar.

Glimepiride is typically started at 1 mg or 2 mg once daily. The dose can then be increased in 1 mg or 2 mg increments every 1–2 weeks based on your blood sugar readings. The maximum recommended dose is 8 mg once daily.

Glimepiride is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take Glimepiride if you are allergic to Glimepiride, any of the product’s ingredients, or to sulfonamide derivatives.

Common side effects of Glimepiride include:

• Shakiness
• Anxiety, and other symptoms of low blood sugar levels
• Headache
• Fever, cough, and other flu-like symptoms
• Nausea
• Dizziness

Serious side effects are rare with Glimepiride. Contact your healthcare provider immediately if you experience any of the following.

• Severe skin or allergic reactions: rash, blisters, sores, trouble breathing, swelling
• Low blood sugar: shakiness, fast heartbeat, sweating, dizziness, anxiety, confusion, feeling very hungry

The following medications may interact with Glimepiride:

• Other medications that affect bloood sugar levels – may require Glimepiride dose adjustment and close monitoring of blood sugar levels
• Miconazole – Severe hypoglycemia can occur when Glimepiride and oral miconazole are used concomitantly
• Inhibitors and inducers of cytochrome P450 2C9 may affect glycemic control by changing Glimepiride plasma concentrations
• Colesevelam – coadministration may reduce Glimepiride absorption. Glimepiride should be administered at least 4 hours prior to colesevelam

Various FDA-approved generic manufacturers

It is not known if Glimepiride will harm your unborn baby. However, it is known that it will cross the placenta and has been associated with neonatal adverse reactions such as hypoglycemia. Therefore, Glimepiride should be discontinued at least two weeks before expected delivery.

• Amaryl