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Glimepiride

Glimepiride Generic

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AVAILABLE CURRENTLY, ONLY IN
United States
*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Glimepiride
    Generic for Amaryl
    Rx
    1mg
    30 tablets $3.6 USD
    Save $4.20
  3. Glimepiride
    Generic for Amaryl
    Rx
    2mg
    30 tablets $3.6 USD
    Save $4.20
  4. Glimepiride
    Generic for Amaryl
    Rx
    4mg
    30 tablets $3.9 USD
    Save $3.90
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Do you need a prescription for glimepiride?

Yes, glimepiride is only available with a valid physician Rx.

How much is glimepiride without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase glimepiride, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for glimepiride in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a glimepiride savings card?

Yes. Save up to 90% on your glimepiride with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a glimepiride coupon provider in the US?

No. Now Patient does not provide glimepiride coupons or FREE glimepiride samples.

Do you accept commercial, Medicare or Medicaid coverage for glimepiride in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much glimepiride?

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Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using glimepiride. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much glimepiride. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

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If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic glimepiride?

Generic glimepiride refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of glimepiride

Glimepiride is approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes mellitus.

Active ingredient of glimepiride

The active ingredient of glimepiride is glimepiride.

US brand name of glimepiride and manufacturer

Glimepiride is available under various brand names in the US, including Amaryl. These medications are manufactured by different pharmaceutical companies.

UK brand name of glimepiride and manufacturer

In the UK, glimepiride is available under various brand names, and the manufacturers may vary.

Prescription requirement for glimepiride

A prescription (Rx) is required for glimepiride in both the US and the UK.

Availability of glimepiride in the UK with NHS prescription

Glimepiride is available in the UK with an NHS prescription.

Conditions treated by glimepiride

It belongs to a class of drugs called sulfonylureas, which work by stimulating the pancreas to produce more insulin and helping the body use insulin more efficiently. Glimepiride helps improve glycemic control and reduce the risk of complications associated with diabetes. Glimepiride is only suitable for people with type 2 diabetes and is not recommended for those with type 1 diabetes or diabetic ketoacidosis.

How does glimepiride work?

Glimepiride belongs to a class of medications called sulfonylureas. It works by stimulating the release of insulin from the pancreas and increasing the sensitivity of tissues to insulin. By increasing insulin production and improving insulin utilization, it helps to lower blood sugar levels and prevent complications associated with high blood sugar. Taking glimepiride as prescribed can help manage diabetes and improve overall health.

Forms of glimepiride available

Glimepiride is available in the form of oral tablets.

Dosage of glimepiride

The dosage of glimepiride may vary depending on the individual patient’s condition, response to treatment, and other factors. It is important to follow the prescribed dosage instructions provided by the healthcare provider. If you forget to take a dose of glimepiride, it is important to take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. It is not recommended to take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, it is best to consult with a healthcare professional. Remember, it is important to take glimepiride consistently as prescribed to effectively control your blood sugar levels.

Directions for glimepiride use

Glimepiride should be taken exactly as directed by the healthcare provider. It is usually taken once daily, preferably with breakfast or the first main meal of the day. It is important to take the medication consistently at the same time each day. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Warnings and precautions for glimepiride

  • Glimepiride may cause low blood sugar levels (hypoglycemia). It is important to monitor blood sugar levels regularly and be aware of the signs and symptoms of hypoglycemia
  • Glimepiride is contraindicated in patients with hypersensitivity to glimepiride or other sulfonylureas
  • It may interact with certain medications, including other antidiabetic drugs, certain antibiotics, and certain cardiovascular medications. It is important to inform the healthcare provider about all medications being taken
  • People with a specific enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency must use caution when taking sulfonylureas. Combining these drugs may cause hemolytic anemia

Drug interactions

When taking glimepiride, it is important to be aware of potential drug interactions to ensure the medication’s effectiveness and avoid any adverse effects. Here are some drugs that may interact with glimepiride:

  • NSAIDs (nonsteroidal anti-inflammatory drugs) like ibuprofen, naproxen and aspirin can increase the risk of low blood sugar (hypoglycemia) when taken with glimepiride. It is important to monitor your blood sugar levels closely if you are taking these medications together
  • Beta-blockers such as propranolol and metoprolol are commonly used to treat conditions like high blood pressure and heart disease. They can mask the symptoms of low blood sugar, making it difficult to recognize and treat hypoglycemia. Regular monitoring of blood sugar levels is essential when taking glimepiride with beta-blockers
  • ACE inhibitors (angiotensin-converting enzyme inhibitors) like lisinopril and enalapril may enhance the hypoglycemic effects of glimepiride, leading to a greater risk of low blood sugar. Regular monitoring of blood sugar levels is recommended when using these medications together with glimepiride
  • Diuretics can increase the risk of low blood glucose when taken with glimepiride. Close monitoring of blood sugar levels is important in this combination
  • Certain antibiotics like fluoroquinolones (ciprofloxacin, levofloxacin) and sulfonamides (sulfamethoxazole, trimethoprim) may interact with glimepiride, leading to an increased risk of low blood sugar. Close monitoring of blood sugar levels is important when using these medications together

It is important to note that this is not an exhaustive list of drug interactions with glimepiride. Always inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter drugs, and herbal supplements. They can help determine if there are any potential interactions or if adjustments need to be made to your glimepiride dosage. Additionally, it is important to be aware of the signs and symptoms of low blood sugar (hypoglycemia) and high blood sugar (hyperglycemia) when taking glimepiride and any other medications. Some common signs of low blood sugar include drowsiness, confusion, weakness, sweating, shaking, and hunger. On the other hand, high blood sugar can cause symptoms such as increased thirst, frequent urination, blurred vision, and fatigue.

Use of glimepiride during pregnancy

Glimepiride is generally not recommended during pregnancy. Consultation with a healthcare provider is necessary to discuss alternative treatment options and medical advice.

Use of glimepiride while breastfeeding

Glimepiride is generally not recommended while breastfeeding. Consultation with a healthcare provider is necessary to discuss alternative treatment options.

Possible side effects of glimepiride

Common side effects of glimepiride may include hypoglycemia, weight gain, dizziness, and gastrointestinal symptoms. Serious side effects are rare but can include severe allergic reactions and liver problems.

Similar drugs to glimepiride

Other medications used to treat type 2 diabetes mellitus include metformin, insulin, and other sulfonylureas such as gliclazide and glipizide.

Sources:

  • FDA Prescribing Information for Glimepiride
  • MHRA product information for Glimepiride
  • NHS UK
  • Drugs.com
  • WebMD
Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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