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Etonogestrel/Ethinyl Estradiol is a hormone combination used by women to prevent pregnancy.

Etonogestrel/Ethinyl Estradiol is a vaginal ring containing 11.7 mg etonogestrel and 2.7 mg ethinyl estradiol, which releases on average 0.12 mg/day of etonogestrel and 0.015 mg/day of ethinyl estradiol.

Etonogestrel/Ethinyl Estradiol contains a combination of two hormones:

• etonogestrel (a progestin) and ethinyl estradiol (an estrogen). These hormones work together to prevent pregnancy in a few ways.
• It stops ovulation (the release of an egg from the ovary).
• It makes the mucus in your cervix thicker so it’s harder for sperm to move through and fertilize an egg.
• It changes the lining of the uterus (womb) so it’s harder for a fertilized egg to attach onto.

Each Etonogestrel/Ethinyl Estradiol releases 0.12 mg of etonogestrel and 15 mcg of ethinyl estradiol per day.

Weeks 1 to 3:

• Insert one ring into the vagina. Then, keep it in place for the next 3 weeks. Take out the ring from the vagina at the end of week 3.
• Week 4: Don’t use any rings this week.
• Keep repeating this 4-week cycle to prevent pregnancy. Insert a new ring on the first day of your next cycle (7 days after you remove the old one).

Etonogestrel/Ethinyl Estradiol is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Blood clots
• Over age 35 and smoke
• Over age 35 and have migraine headaches
• Migraine headaches with aura
• Currently have or have had a blood clot (DVT or PE)
• History of stroke
• Coronary artery disease (CAD)
• Certain heart rhythm problems, like atrial fibrillation (AFib)
• Uncontrolled high blood pressure
• Medical conditions that make clotting easier
• Diabetes with long-term complications
• Liver tumors or other liver problems
• Currently pregnantlood clots
• Over age 35 and smoke
• Over age 35 and have migraine headaches
• Migraine headaches with aura
• Currently have or have had a blood clot (DVT or PE)
• History of stroke
• Coronary artery disease (CAD)
• Certain heart rhythm problems, like atrial fibrillation (AFib)
• Uncontrolled high blood pressure
• Medical conditions that make clotting easier
• Diabetes with long-term complications
• Liver tumors or other liver problems
• Currently pregnant

Common side effects of Etonogestrel/Ethinyl Estradiol:

• Nflammation or irritation of the vagina
• Headache, including migraine
• Mood changes
• Device-related events
• Nausea or vomiting
• Vaginal discharge
• Weight gain

Serious side effects are rare with Etonogestrel/Ethinyl Estradiol. Contact your healthcare provider immediately if you experience any of the following:

• Stroke: sudden changes in vision, speech, balance, or coordination; face drooping; sudden weakness in one arm; severe headache; confusion
• Heart attack: chest pain, arm pain, sweating, shortness of breath
• Deep vein thrombosis (blood clot in the leg): tenderness, swelling, or pain in the leg that doesn’t go away
• Pulmonary embolism (blood clot in the lung): sudden shortness of breath, cough, chest pain, racing heart
• Liver or gallbladder problems: yellow skin or eyes, pain in the upper right side of the stomach, dark urine
• Toxic shock syndrome (TSS): sudden high fever, skin redness that looks like a sunburn, body aches, headache, sore throat, vomiting, diarrhea, dizziness
• Serious allergic reaction: swelling of the face, mouth, or tongue; swelling around the eyes; swelling of the throat; trouble breathing; anaphylaxis

The following medications may interact with Etonogestrel/Ethinyl Estradiol:

• Drugs or herbal products that induce certain enzymes, such as CYP3A4.

Various FDA-approved generic manufacturers

Etonogestrel/Ethinyl Estradiol is not to be used during pregnancy. If pregnancy is planned or occurs during treatment with Etonogestrel/Ethinyl Estradiol, stop using this medication and call your doctor.

• Nuvaring