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Eculizumab-AEEB is available as a 300 mg/30 mL (10 mg/mL) single-dose vial.

Eculizumab-AEEB is a complement inhibitor indicated for: The treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) to reduce hemolysis. The treatment of patients with atypical hemolytic uremic syndrome (aHUS) to inhibit complement-mediated thrombotic microangiopathy.

The exact ways that Eculizumab-AEEB works to treat these conditions aren’t known, but it’s thought to help by stopping the complement system. This stops the body’s immune system from attacking itself.

Eculizumab-AEEB is given by intravenous infusion over 35 minutes in adults and 1 to 4 hours in pediatric patients via gravity feed, a syringe-type pump, or an infusion pump.

Eculizumab-AEEB is a safe and effective treatment when used for FDA approved indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take Eculizumab-AEEB is you have an unresolved serious Neisseria meningitidis infection.

Common side effects of Eculizumab-AEEB: Headache, Nose and throat infection, Back pain Nausea, Tiredness, Cough, Fever, Diarrhea, High blood pressure, Vomiting Joint pain

Serious side effects are rare with Eculizumab-AEEB. Contact your healthcare provider immediately if you experience any of the following: Meningococcal infection: headache, stiff neck or back, muscle ache, nausea, vomiting, fever, flu-like symptoms, sensitivity to bright light, confusion, rash Serious infusion-related reactions: chest pain, trouble breathing or shortness of breath, feeling faint or wanting to pass out, swelling of face, tongue, or throat Blood clots, other blood problems, or worsening of aHUS: stroke confusion, seizures, difficulty breathing, chest pain, kidney problems, swelling in arms or legs

There are no drug interactions listed for Eculizumab-AEEB.

Various FDA-approved generic manufacturers

It is not known whether Eculizumab-AEEB will harm your unborn baby. Talk with your healthcare provider about the risks of taking this medication if you are pregnant or plan on becoming pregnant.

• Bkemv