dordaviprone
Used for Cancer
NowPatient can significantly lower the cost* of your prescription medication by providing free access to drug coupons, savings cards, patient assistance programs and other out of pocket discount programs. Whether you’re insured, uninsured, or underinsured, we empower you with transparency and cost-saving tools to make your dordaviprone more affordable.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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Rx Advantage Card
Our savings card can be used in over 65,000 pharmacies and could save you up to 90% on the cost of your medication. Suitable for insured, underinsured and uninsured individuals. This is not health insurance and cannot be used in conjunction with insurance.
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Drug Coupons
For those who are commercially insured, drug manufacturer coupons can help reduce your out-of-pocket costs. Eligible for commercially insured only.
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Patient Assistance Programs
Patient assistance programs (PAPs) are sponsored by pharmaceutical companies and can mean you can obtain your medications at no cost to you. Suitable for insured, underinsured and uninsured individuals who are financially constrained.
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MEDICAL INFORMATION
dordaviprone Key Facts
What is dordaviprone?
Dordaviprone is the brand name for Modeyso, a targeted anti-cancer medication used to treat diffuse midline glioma with an H3 K27M mutation, an aggressive brain tumour affecting both adults and children aged 1 year and older.
What dosages is dordaviprone available in?
Dordaviprone (Modeyso) is available as oral capsules in the following strengths:
- 125 mg
What is dordaviprone used for?
Dordaviprone is indicated for use in adult and pediatric patients aged 1 year and older with diffuse midline glioma that harbors an H3 K27M mutation and has progressed following prior therapy. This approval was granted under the FDA’s accelerated approval pathway, making dordaviprone the first, and currently only, systemic treatment option for this rare and aggressive form of brain tumor.
How does dordaviprone work?
Dordaviprone works by inhibiting specific pathways that drive tumor growth in diffuse midline glioma with the H3 K27M mutation. It targets cancer cells to slow or stop their proliferation, helping manage disease progression in patients whose tumors have continued to grow following prior therapy. Dordaviprone works by activating the mitochondrial protease ClpP and inhibiting the dopamine D2 receptor, helping to slow tumour growth and induce cancer cell death.
How do I take dordaviprone?
Dordaviprone (Modeyso) is administered as an oral capsule once weekly. The recommended dosage is:
- Adults and pediatric patients weighing ≥52.5 kg: 625 mg orally once weekly.
- Pediatric patients aged 1 year and older weighing between 10 kg and <52.5 kg: The dosage varies based on body weight, ranging from 125 mg to 500 mg once weekly.
Dordaviprone should be taken on an empty stomach, at least 1 hour before or 3 hours after eating. If swallowing capsules is not possible, the contents can be mixed with approximately 15 to 30 mL of liquid (such as water, apple juice, lemonade, or a sports drink) before ingestion.
Always follow your healthcare provider’s instructions regarding how and when to take dordaviprone.
Is it safe for me to take dordaviprone?
Dordaviprone is generally safe and effective for most patients when used as directed. However, it may not be suitable if you have certain health conditions or are taking specific medications.
Do not take dordaviprone if you have:
- Severe hypersensitivity to dordaviprone or any of its ingredients.
- QTc interval prolongation or a history of arrhythmias.
- Severe liver impairment.
- Known hypersensitivity to dordaviprone or any of its ingredients.
- Used another protease activator or similar medication within the last 24 hours.
dordaviprone Common Side Effects
Common side effects of dordaviprone include:
- Fatigue
- Headache
- Nausea
- Vomiting
- Musculoskeletal pain
These side effects occurred in more than 20% of patients during clinical trials.
dordaviprone Serious Side Effects
Serious side effects of dordaviprone are not common. However, you should seek immediate medical attention if you experience:
- Allergic reactions: Rash, itching, swelling, difficulty breathing
- Heart rhythm problems: Palpitations, dizziness, or fainting
- Neurological symptoms: Seizures, confusion, sudden numbness or weakness
Effects of other drugs, drug classes and over-the-counter products on dordaviprone
Dordaviprone may be affected by certain drug classes. You should inform your doctor if you are taking:
- Strong or moderate CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): These can increase dordaviprone exposure, potentially increasing the risk of dordaviprone-related adverse reactions.
- Strong or moderate CYP3A4 inducers (e.g., rifampin, carbamazepine): These can decrease dordaviprone exposure, potentially reducing its anti-tumor activity.
- Medications that prolong the QTc interval (e.g., certain antiarrhythmics, antipsychotics): Concomitant use with dordaviprone may increase the risk of QTc-associated arrhythmias.
Always discuss all medications, including over-the-counter products, with your healthcare provider before starting dordaviprone.
Who makes dordaviprone?
Various FDA-approved generic manufacturers
Is dordaviprone safe in pregnancy?
Dordaviprone (Modeyso) is not recommended during pregnancy. Animal studies showed risk of fetal harm, and the FDA classifies it as a drug with known fetal risk.
Women of reproductive potential should have a pregnancy test before starting treatment and use effective contraception during treatment and for 1 month after the last dose. Men with female partners of reproductive potential should also use contraception.
If you become pregnant while taking dordaviprone, contact your doctor immediately to discuss risks and options.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A Practical Guide to Saving Money and Receiving Support With Prescription Drug Costs
How can NowPatient help me to lower the cost of my dordaviprone prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your dordaviprone prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient dordaviprone savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient dordaviprone savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for dordaviprone | Canadian Prescription Savings* for dordaviprone | dordaviprone Drug Coupon* | dordaviprone Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of dordaviprone?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for dordaviprone | Canadian Prescription Savings* for dordaviprone | dordaviprone Drug Coupon* | dordaviprone Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the dordaviprone savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the dordaviprone drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for dordaviprone, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the dordaviprone prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, dordaviprone is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed dordaviprone for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the dordaviprone prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the dordaviprone prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for dordaviprone
If you are having trouble paying for your dordaviprone medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for dordaviprone you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- dordaviprone is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers dordaviprone
- If dordaviprone is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for dordaviprone
If you are having trouble paying for your dordaviprone medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for dordaviprone you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers dordaviprone
- If dordaviprone is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for dordaviprone
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your dordaviprone treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for dordaviprone you will need to meet the following criteria:
- You must be currently insured and have coverage for dordaviprone
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.