divalproex sodium
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Manufactured by various FDA-approved generic manufacturers.
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divalproex sodium Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is divalproex sodium available in?
divalproex sodium is available as a 250 mg and 500 mg extended-release oral tablet.
What is divalproex sodium used for?
divalproex sodium is an antiepileptic and is used to treat bipolar disorder,
seizures (focal impaired awareness seizure, absence seizure), and migraine prevention.
How does divalproex sodium work?
divalproex sodium is an antiepileptic. It’s not exactly clear how this medication works to prevent migraines or treat mania episodes in bipolar. But in order to control seizures, divalproex sodium signals your brain to make more of a chemical called gamma-aminobutyric acid (GABA). GABA helps to reduce the bursts of activity in your brain, which prevents seizures.
How do I take divalproex sodium?
divalproex sodium is typically taken by mouth up to a maximum dose of 1000 mg once a day.
Is it safe for me to take divalproex sodium?
divalproex sodium is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you have hepatic disease or significant hepatic dysfunction, known mitochondrial disorders caused by mutations in mitochondrial DNA
polymerase γ (POLG), suspected POLG-related disorder in children under two years of age, a known hypersensitivity to the drug, urea cycle disorder, or are using it for the prophylaxis of migraine headaches and are pregnant or could become pregnant and not using effective contraception.
divalproex sodium Common Side Effects
Common side effects of divalproex sodium include:
- Nausea
- Excess sleepiness
- Accidental injury
- Low energy
- Headache
- Feeling weak
- Vomiting
- Tremor
- Dizziness
- Stomach pain
divalproex sodium Serious Side Effects
Serious side effects are rare with divalproex sodium. Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts or behaviors
- Severe allergic reactions: fever, rash, extreme tiredness, body aches, mouth sores, blisters, trouble breathing
- Serious liver problems: nausea, vomiting, not feeling hungry, pain in the right side of the stomach, yellowing of the whites of the eyes or skin, dark-colored urine, light-colored stool
- Extremely high blood ammonia levels: fatigue, poor mental alertness, vomiting
- Inflamed pancreas: upper stomach pain, fever, nausea, vomiting
- Serious bleeds: bleeding that’s difficult to stop, vomiting blood, blood in the urine or stool, “coffee-ground” stool
- Extreme drop in body temperature: shivering, feeling tired, feeling confused, slurred speech, coma
Effects of other drugs, drug classes and over-the-counter products on divalproex sodium
The following medications may interact with divalproex sodium:
- Hepatic enzyme-inducing drugs (e.g., phenytoin, carbamazepine, phenobarbital, primidone, rifampin) can increase divalproex sodium clearance, while enzyme inhibitors (e.g., felbamate) can decrease divalproex sodium clearance
- Aspirin, carbapenem antibiotics – Monitoring of divalproex sodium concentrations is recommended
- Co-administration of divalproex sodium can affect the pharmacokinetics of other drugs (e.g. diazepam, ethosuximide, lamotrigine, phenytoin) by
- inhibiting their metabolism or protein binding displacement
- Dosage adjustment of amitryptyline/nortryptyline, warfarin, and zidovudine may be necessary if used concomitantly with divalproex sodium
- Topiramate – Hyperammonemia and encephalopathy.
Who makes divalproex sodium?
Various FDA-approved generic manufacturers
Is divalproex sodium safe in pregnancy?
divalproex sodium can cause congenital malformations including neural tube defects and decreased IQ. Only use divalproex sodium to treat pregnant women with epilepsy if other medications are unacceptable.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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