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Chlorpromazine is available as a 30 mg/ml and 100 mg/ml oral concentrate and a 10 mg, 25 mg, 50 mg, 100 mg, and 200 mg oral tablet.

Chlorpromazine is a typical antipsychotic that is used for:

• Management of psychotic disorders
• Schizophrenia
• Nausea and vomiting
• Restlessness and anxiety before surgery
• Acute intermittent porphyria
• Tetanus
• Manic episodes of bipolar disorder
• Hiccups that won’t go away
• Severe behavioral issues in children 1 to 12 years old (e.g., aggressive behavior, frustration, explosive or hyperexcitable behavior)

Chlorpromazine is an antipsychotic medication. It works by controlling dopamine activity in your brain, which affects your thoughts and mood. It also helps relax you and lowers nausea and vomiting.

Chlorpromazine dose varies depending on the condition you’re taking Chlorpromazine for. In general, the typical dose ranges from 10 mg to 50 mg by mouth two to four times a day. If you’re taking Chlorpromazine for restlessness and anxiety before surgery, the typical dose is 25 mg to 50 mg by mouth once, 2 to 3 hours before your procedure.

Chlorpromazine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:

• Circulatory collapse.
• CNS depression, e.g. coma or drug intoxication.
  Previous history of a hypersensitivity reaction (e.g. jaundice or blood dyscrasia) to phenothiazines, especially Chlorpromazine itself, or to any of the excipients contained in the tablets or injection
• Bone marrow depression
• Phaeochromocytoma
• Hepatic failure or active hepatic disease

Common side effects of Chlorpromazine:

• Drowsiness
• Uncontrollable muscle movements (e.g., neck spasms, difficulty swallowing and breathing, sticking your tongue out)
• Dry mouth
• Stuffy nose
• Nausea
• Constipation
• Bladder problems

Serious side effects are rare with Chlorpromazine. Contact your healthcare provider immediately if you experience any of the following.

• Neuroleptic malignant syndrome: high fever, fast heart rate, full body stiffness, and confusion
• Very low blood pressure
• Seizures

The following medications may interact with Chlorpromazine:

• Interactions resulting in decreased Chlorpromazine levels
• Food, alcohol and benztropine can reduce the absorption of Chlorpromazine. Antacids can slow the absorption of Chlorpromazine. Lithium and chronic administration of barbiturates can lead to increased clearance of Chlorpromazine
• Interactions resulting in increased Chlorpromazine levels
• Tricyclic antidepressants decrease the clearance of Chlorpromazine and may lead to increased serum levels.
• Administration of Chlorpromazine with CYP1A2 inhibitors, in particular strong (such as ciprofloxacin and fluvoxamine) or moderate (such as oral contraceptives and vemurafenib) inhibitors leads to an increase in Chlorpromazine plasma concentrations. Therefore, patients may experience any Chlorpromazine dose-dependent adverse drug reaction

Various FDA-approved generic manufacturers

Chlorpromazine should not be used in pregnant women, or those likely to become pregnant, unless the expected benefit outweighs any potential risk.

• Thorazine