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Celecoxib is available as a 50 mg, 100 mg, 200 mg, and 400 mg oral capsule.

Celecoxib is a COX-2 selective NSAID used for osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis (AS), sudden pain, and menstrual cramps.

Celecoxib is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It works by blocking a protein called cyclooxygenase-2 (or COX-2) that’s involved in causing pain and swelling. By blocking COX-2, this medication eases pain and swelling. In contrast to most other NSAIDs, Celecoxib doesn’t affect the COX-1 proteins protecting your stomach and gut. Blocking COX-2 rather than COX-1 is thought to explain why Celecoxib generally has a lower risk for stomach bleeding and ulcers.

Celecoxib is typically taken by mouth once or twice daily. The dose might differ if you or your child has liver problems.

Celecoxib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known hypersensitivity to Celecoxib, or any components of the drug product or sulfonamides or if you have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It should also not be used for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Common side effects of Celecoxib include:

• Headache
• Indigestion
• Upper respiratory infection
• Diarrhea
• Sinus infection (congestion, runny nose)
• Belly pain
• Passing gas

Serious side effects are rare with Celecoxib. Contact your healthcare provider immediately if you experience any of the following.

• Heart attack: trouble breathing, chest pain or tightness
• Heart failure: trouble breathing, tiredness, swelling in your body, sudden weight gain
• Stroke: blurred vision, difficulty speaking, difficulty walking, weakness on one side of the body
• Stomach or gut bleeds: blood in your vomit, stool that looks like black coffee grounds, pain in your stomach that doesn’t go away
• Severe asthma attack: chest pain, cough, difficulty breathing, wheezing
• Serious allergic or skin reaction: fever, body aches, cough, peeling skin, rash, painful blisters all over your body, trouble breathing, swelling of the face

The following medications may interact with Celecoxib:

• Drugs that Interfere with Hemostasis (e.g., warfarin, aspirin, selective serotonin reuptake inhibitors [SSRIs]/serotonin norepinephrine reuptake inhibitors [SNRIs]) – Monitor patients for bleeding who are concomitantly taking Celecoxib with drugs that interfere with hemostasis. Concomitant use of Celecoxib and analgesic doses of aspirin is not generally recommended
• Angiotensin Converting Enzyme (ACE) Inhibitors, Angiotensin Receptor Blockers (ARB), or Beta-Blockers – Concomitant use with Celecoxib may diminish the antihypertensive effect of these drugs. Monitor blood pressure
• ACE Inhibitors and ARBs – Concomitant use with Celecoxib in elderly, volume depleted, or those with renal impairment may result in deterioration of renal function. In such high risk patients, monitor for signs of worsening renal function
• Diuretics – NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics. Monitor patients to assure diuretic efficacy including antihypertensive effects

Digoxin: Concomitant use with Celecoxib can increase serum concentration and prolong half-life of digoxin. Monitor serum digoxin levels.

Various FDA-approved generic manufacturers

Celecoxib should avoided in late pregancy as it may cause harm to your unborn baby. If you become pregnant while receiving Celecoxib, talk to your healthcare provider.

• Celebrex