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Carbatrol is the brand name for carbamazepine and available as an extended-release oral capsule.

Carbatrol is available as a 100 mg, 200 mg, and 300 mg extended-release oral capsule.

Carbatrol is an antiepileptic and is used for the following:

• Partial-onset seizures
• Generalized tonic-clonic seizures
• Mixed seizure patterns
• Trigeminal neuralgia (facial nerve pain)
• Bipolar I disorder – Equetro brand only

Carbatrol is an antiepileptic known as a sodium channel blocker. It’s thought to work by blocking the activity of certain nerves in your brain.

Carbatrol is typically dosed as the following:

• Ages 12 years and older: The typical starting dose is 200 mg by mouth twice per day. The maximum dose ranges from 500 mg to 800 mg twice daily, depending on age
• Ages under 12 years: Your child’s provider will calculate the dose based on your child’s weight and if they were taking IR forms of carbamazepine before. The maximum dose is typically 35 mg/kg by mouth per day

Carbatrol is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:

• History of bone marrow problems
• Sensitivity to medications known as tricyclic medications, such as amitriptyline, imipramine, and nortriptyline (Pamelor)
• Have taken monoamine oxidase inhibitors (MAOIs) within 14 days of starting treatment
• Taking nefazodone with carbamazepine (Tegretol)
• Taking non-nucleoside reverse transcriptase inhibitors (certain HIV antiviral medications) with Equetro or Carbatrol

Common side effects of Carbatrol:

• Dizziness
• Sleepiness
• Nausea
• Vomiting
• Difficulty walking or keeping balance
• Constipation
• Itching
• Dry mouth
• Weakness
• Rash
• Blurry vision
• Speech problems

Serious side effects are rare with Carbatrol. Contact your healthcare provider immediately if you experience any of the following.

• Suicidal behavior or thoughts of self-harm
• Serious allergic and skin reactions: sore throat, fever, fatigue, rash, hives, painful blisters, skin reddening, skin peeling, swollen lymph nodes
• Low blood cell counts: fever, trouble breathing, chills weakness, unusual bruising or bleeding, and blood in urine, stools, or gums
• Liver problems: severe nausea, vomiting, right-sided stomach pain, fatigue, low or no appetite, yellowing of the skin or eyes
• Low blood sodium levels: nausea, fatigue, headache, confusion, disoriented, hallucinations (seeing things that aren’t real), seizures, unconsciousness

The following medications may interact with Carbatrol:

• Agents Highly Bound to Plasma Protein: Administration of Carbatrol to a patient taking another drug that is highly protein bound should not cause increased free concentrations of the other drug
• Agents that Inhibits Cytochrome P450 Isoenzymes and/or Epoxide Hydrolase: Potential interaction between Carbatrol and any agent that inhibits CYP3A4 and/or epoxide hydrolase such as: Acetazolamide, azole antifungals, cimetidine, clarithromycin, dalfopristin, danazol, delavirdine
• diltiazem, erythromycin, fluoxetine, fluvoxamine, grapefruit juice, isoniazid, itraconazole ketoconazole, loratadine, nefazodone, niacinamide, nicotinamide, protease inhibitors propoxyphene, quinine, quinupristin, troleandomycin, valproate, verapamil, zileuton
• Agents that Induce Cytochrome P450 Isoenzymes: Agents that are CYP inducers that have been found, or are expected, to decrease plasma levels of Carbatrol are the following: Cisplatin, doxorubicin HCL, felbamate, rifampin, phenobarbital, phenytoin(2), primidone methsuximide, and theophylline
• Agents with Decreased Levels in the Presence of Carbamazepine due to Induction of Cytochrome P450 Enzymes: Potential exists for interaction between Carbatrol and any agent metabolized by one (or more) of these enzymes such as acetaminophen, alprazolam, amitriptyline, bupropion, buspirone, citalopram, clobazam clonazepam, clozapine, cyclosporin, delavirdine, desipramine, diazepam, dicumarol, doxycycline ethosuximide, felbamate, felodipine, glucocorticoids, haloperidol, itraconazole, lamotrigine levothyroxine, lorazepam, methadone, midazolam, mirtazapine, nefazodone, nortriptyline
• olanzapine, oral and other hormonal contraceptives oxcarbazepine, phenytoin, praziquantel  protease inhibitors, quetiapine, risperidone, theophylline, topiramate, tiagabine, tramadol, triazolam trazodone, valproate, warfarin, ziprasidone, and zonisamide

Shire US Inc.

Carbatrol can cause fetal harm when administered to a pregnant woman. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Carbamazepine