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AprepitantPrices, Coupons & Savings
Looking for ways to save up to 90%* on your FDA-approved branded and generic medications?
You could enjoy savings using Now Patient’s mail-order online pharmacy or the Now Patient Rx Advantage Card at over 65,000 pharmacies.
AVAILABLE CURRENTLY, ONLY IN
United States
Mail Order Pharmacy
- MedicationYou saveUS ONLY
- AprepitantGeneric for EmendRx125mg93 capsules $1607.1 USD93 capsules $1607.1 USD - 17.28 USD/capsuleSave $6737.79
- AprepitantGeneric for EmendRx40mg30 capsules $522.6 USD30 capsules $522.6 USD - 17.42 USD/capsuleSave $2169.30
- AprepitantGeneric for EmendRx80mg60 capsules $1035.3 USD60 capsules $1035.3 USD - 17.25 USD/capsuleSave $4348.50
Do you need a prescription for aprepitant?
Yes, aprepitant is only available with a valid physician Rx.
How much is aprepitant without Insurance in the US?
Our website gives two competitive savings options to US customers who wish to purchase aprepitant, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.
What will my out-of-pocket cost be for aprepitant in the US?
There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.
Is Now Patient a aprepitant savings card?
Yes. Save up to 90% on your aprepitant with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.
Can you handle Rx transfers for home delivery in the US?
Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.
Is Now Patient a aprepitant coupon provider in the US?
No. Now Patient does not provide aprepitant coupons or FREE aprepitant samples.
Do you accept commercial, Medicare or Medicaid coverage for aprepitant in the US?
No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.
Does Now Patient work with Medicare?
Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.
Does Now Patient work with Commercial Insurance?
Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.
What should you do if you use too much aprepitant?
USCall your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using aprepitant. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much aprepitant. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.
UKIf you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.
What should I do if I miss my dose?
There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.
Click here to find out what to do if you forgot to take your medication
What is generic aprepitant?
Generic aprepitant refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.
FDA approval of aprepitant
Aprepitant is approved by the U.S. Food and Drug Administration (FDA) for the prevention of chemotherapy-induced nausea and vomiting (CINV).
Active ingredient of aprepitant
The active ingredient of aprepitant is aprepitant.
US brand name of aprepitant and manufacturer
Aprepitant is available in the US under the brand name Emend. The manufacturer of Emend may vary.
UK brand name of aprepitant and manufacturer
In the UK, aprepitant is available under the brand name Emend. The manufacturer of Emend may vary.
Prescription requirement for aprepitant
A prescription (Rx) is required for aprepitant in both the US and the UK.
Availability of aprepitant in the UK with NHS prescription
Aprepitant is available in the UK with an NHS prescription.
Conditions treated by aprepitant
Aprepitant is primarily used for the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients undergoing cancer treatment.
- Chemotherapy-induced nausea and vomiting (CINV)
- Post-operative nausea and vomiting (PONV)
- Radiotherapy-induced nausea and vomiting (RINV)
- Delayed nausea and vomiting
- Breakthrough nausea and vomiting
- Pediatric patients with chemotherapy-induced nausea and vomiting
How does aprepitant work?
Aprepitant belongs to the class of neurokinin-1 receptor antagonist medications. It works by blocking the neurotransmitter substance P in the brain. Substance P plays a role in triggering chemotherapy-induced nausea and vomiting (CINV). By preventing the signals that trigger CINV, aprepitant helps to alleviate these symptoms during treatment. The mechanism of action of aprepitant involves its selective affinity as an antagonist for neurokinin 1 (NK1) receptors. NK1 receptors are found in both the central nervous system and peripheral tissues. Aprepitant’s high affinity for NK1 receptors allows it to effectively block substance P, reducing the occurrence of nausea and vomiting associated with chemotherapy. It is important to note that aprepitant is often given as part of a combination regimen with other antiemetic agents, such as a 5-HT3 receptor antagonist and a corticosteroid like dexamethasone, to provide comprehensive protection against chemotherapy-induced nausea and vomiting.
Forms of aprepitant available
Aprepitant capsules are the most common form of aprepitant. These capsules are taken by mouth, usually once a day, with or without food. They are designed to release the medication slowly into your body, ensuring a steady level of aprepitant in your system. In some cases, aprepitant may be given to you through an intravenous (IV) infusion. This is usually done in a medical setting, such as a hospital or clinic, by a healthcare professional. The injectable form of aprepitant provides a rapid onset of action and is ideal for patients who are unable to take medications orally. Aprepitant is sometimes available in combination packs along with other medications to enhance its effectiveness. These packs may contain aprepitant, a 5-HT3 receptor antagonist (such as ondansetron), and a corticosteroid (such as dexamethasone or methylprednisolone). Using these combination packs can help provide better control of nausea and vomiting for patients undergoing chemotherapy.
Dosage of aprepitant
The dosage of aprepitant may vary depending on the specific chemotherapy regimen and individual patient factors. It is important to follow the recommended dosage instructions provided by the healthcare provider. For the prevention of chemotherapy-induced nausea and vomiting in adults, the recommended dose of aprepitant is 125 mg capsule taken orally one hour before chemotherapy, followed by 80 mg once daily in the morning for the next two days. It is usually used in combination with other antiemetic medications. In pediatric patients aged 6 months and older, the recommended dose of aprepitant for chemotherapy-induced nausea and vomiting is based on body weight.
Directions for aprepitant use
Aprepitant should be taken as directed by the healthcare provider. The specific instructions may include the timing of administration, dosage adjustments, and any necessary precautions. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
What is the pharmacokinetics of aprepitant?
Aprepitant is a medication used to prevent nausea and vomiting associated with chemotherapy. Understanding the pharmacokinetics of a drug is essential in determining its absorption, distribution, metabolism, and elimination from the body.
- Absorption: Aprepitant is administered orally as a capsule or a suspension. It is well absorbed in the gastrointestinal tract, with peak plasma concentrations achieved within 3 hours after oral administration
- Distribution: Aprepitant has a high protein-binding capacity, primarily binding to plasma albumin. The volume of distribution is approximately 70 litres, indicating that it is widely distributed throughout the body
- Metabolism: Aprepitant undergoes extensive metabolism in the liver through the cytochrome P450 enzyme system, mainly CYP3A4. It is primarily metabolized into its active metabolite, aprepitant hydrolysis product (AHP), which also exhibits antiemetic activity. Aprepitant is considered a moderate inhibitor of CYP3A4, which can affect the metabolism of other drugs that are substrates of this enzyme.
- Elimination: The elimination half-life of aprepitant is approximately 9 to 13 hours. It is primarily excreted in the feces, with minimal renal excretion (less than 1% of the dose). Aprepitant, as well as their metabolites, undergo enterohepatic circulation, which means they are reabsorbed from the intestine and returned to the liver before being eliminated
When taken orally, aprepitant has a bioavailability of approximately 60-65%. This means that about 60-65% of the medication is absorbed into the bloodstream after oral administration. The remaining percentage is either metabolized or eliminated from the body.
Warnings, precautions and contraindications for aprepitant
- Aprepitant may interact with certain medications, including some commonly used chemotherapy drugs, and dosage adjustments or close monitoring may be necessary
- Common drugs that may interact with aprepitant include blood thinners like warfarin, benzodiazepines, diltiazem, antibiotics such as clarithromycin and antifungal medications such as ketoconazole and itraconazole
- It is important to inform the healthcare provider about any existing medical conditions, allergies, and any other medications or supplements you are currently taking, to avoid potential drug interactions and adverse effects
- Affinity for CYP3A4 enzymes may affect medication metabolism. Coadministration of aprepitant with strong CYP3A4 inducers (eg, rifampin, carbamazepine, phenytoin) may result in a substantial reduction in aprepitant plasma concentrations and decreased efficacy
- Some individuals may be allergic to aprepitant, resulting in serious reactions. If you notice any signs of an allergic reaction such as rash, itching, swelling, dizziness, or difficulty breathing, seek immediate medical attention and discontinue the use of aprepitant until advised by a healthcare professional
- Consult your doctor before using aprepitant during pregnancy or breastfeeding
- The effectiveness of hormonal contraceptives may be reduced if taken at the same time as aprepitant. It is advised to use different forms of birth control
Possible side effects of aprepitant
Common side effects of aprepitant may include tiredness, hiccups, headache, dizziness, constipation, diarrhea, and changes in taste. If these side effects persist or worsen, it is important to contact a healthcare provider.
Similar drugs to aprepitant
Other medications used for the prevention of chemotherapy-induced nausea and vomiting (CINV) include ondansetron, granisetron, and palonosetron.
Sources
Disclaimer
Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Pharmacist / B.Pharm
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