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Is the cost of your aprepitant too expensive?

You may qualify for programs where you can pay as little as $0 per fill, subject to income and insurance status.

This content is intended for US audiences only

NowPatient offers cost effective access to aprepitant for everyone including those who are uninsured, those who have commercial insurance as well as those who are enrolled into state or federal programs like Medicaid, Medicare Part D, full Low Income Subsidy (LIS, “Extra Help”), TRICARE or Veterans (VA) Benefits.

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Table of contents
OverviewWhat can I do if I am commercially insured but cannot afford my aprepitant?What can I do if I am uninsured and cannot afford my aprepitant?What can I do if I am insured with Medicare and cannot afford my aprepitant?Am I eligible for the Rx Advantage Card and how much does aprepitant cost without insurance?What will my out-of-pocket cost be for aprepitant when using the Rx Advantage Card?Is it legal for me to pay cash for aprepitant even though I have insurance?Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?Does the Rx Advantage Card work with Commercial Insurance?How do I check prices for aprepitant and how do I use the Rx Advantage Card?Do I need to pay for the Rx Advantage Card?Is there a aprepitant co-pay program?Is there a aprepitant Patient Assistance Program (PAP)?What should I do if I take too much aprepitant?What are the benefits of NowPatient?What is generic aprepitant?FDA approval of aprepitantActive ingredient of aprepitantUS brand name of aprepitant and manufacturerUK brand name of aprepitant and manufacturerPrescription requirement for aprepitantAvailability of aprepitant in the UK with NHS prescriptionConditions treated by aprepitantHow does aprepitant work?Forms of aprepitant availableDosage of aprepitantDirections for aprepitant useWhat is the pharmacokinetics of aprepitant?Warnings, precautions and contraindications for aprepitantPossible side effects of aprepitantSimilar drugs to aprepitantSourcesPeople also asked
Navin Khosla NowPatientGreen tick
Medically reviewed by Navin Khosla, BPharm and written by Rajive Patel, BPharm - Updated on 25 Jan 2024
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What can I do if I am commercially insured but cannot afford my aprepitant?

If you are commercially insured and you cannot afford your copay or co-insurance you can opt for purchasing aprepitant outside of your plan using the Rx Advantage card, with costs that are usually lower than a typical plan copay. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

If you cannot afford the cash price possibly due to income constraints, then there is the option of applying to state assistance programs like Medicaid. Often, you may be able to receive your aprepitant without any costs at all. You can check Medicaid eligibility in your state by following this link HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application.

What can I do if I am uninsured and cannot afford my aprepitant?

If you cannot afford the cash price of aprepitant using the Rx Advantage card then there is the option of applying to state programs like Medicaid. Often, you may be able to receive your aprepitant without any costs at all. You can check Medicaid eligibility in your state by following this link HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application.

What can I do if I am insured with Medicare and cannot afford my aprepitant?

If you are insured with Medicare and have Part D or an Advantage drug plan but cannot afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you have a number of options:

Option

Savings Information

RX ADVANTAGE CARD

You can use the Rx Advantage to purchase the medication outside of your plan at prices that may be lower than you copay or co-insurance element. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

LOW INCOME SUBSIDY

If this is still too expensive or unaffordable then you can apply for federal support like Low Income Subsidy (LIS). To be eligible for Low Income Subsidy, you need to be resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).

MEDICAID

Alternatively, you can check Medicaid eligibility in your state by following this link to the HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

Am I eligible for the Rx Advantage Card and how much does aprepitant cost without insurance?

Our website gives savings options to customers who wish to purchase aprepitant, as either a brand or generic, without the constraints of insurance. By using the Rx Advantage Card, users can save up to 90% on the cost of their medication. The card can be used at over 65,000 pharmacies nationwide, across America. Even if you are insured, in most cases the cash price will be significantly cheaper than your existing co-pay. NowPatient is able to negotiate discounts on bulk drug purchases with pharmacy owners meaning you can access lower medication prices at nearby pharmacies using our card that can be conveniently stored in your NowPatient account.

What will my out-of-pocket cost be for aprepitant when using the Rx Advantage Card?

Your out-of-pocket (OOP) cost will effectively be the discounted cash price you pay for aprepitant using the Rx Advantage Card. If you are insured, your OOP expense can not be used against your plan deductible, if your plan has a deductible.

Yes. The Rx Advantage card is especially useful for people who have High-deductible health plans (HDHPs). It can be used for insured, uninsured, and underinsured persons.

Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?

No. We do not bill any federal or state insurance including Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug benefit). When you purchase your medication using the NowPatient Rx Advantage Card, you will be doing so out of pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket aprepitant cash price you pay can be typically cheaper than your plan copay.

Does the Rx Advantage Card work with Commercial Insurance?

We do not bill your commercial insurance. When you purchase your medication using the Rx Advantage Card, from NowPatient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket aprepitant cash price you pay can be typically cheaper than your plan copay.

How do I check prices for aprepitant and how do I use the Rx Advantage Card?

You can search for the prices at nearby pharmacies using our website. Simply search your medication and enter your ZIP Code and we will show you the price of your drug at nearby pharmacies. If you are happy with the quote, you need to create an account with NowPatient and generate your card. Next, simply go to the pharmacy and fill your aprepitant Rx. Ask the pharmacy to run the card and check the price, even if they tell you they have another card they use. Your card is stored safely in your NowPatient account.

Do I need to pay for the Rx Advantage Card?

No. The Rx Advantage prescription savings card is FREE to use and store for NowPatient users.

Is there a aprepitant co-pay program?

Generic medications like aprepitant do not have co-pay card savings options. A Copay program, if available, would normally be for the brand name version of aprepitant. You can search the brand name of aprepitant and check to see if a co-pay program exists. Co-pay cards are programs run by pharmaceutical companies that offer you a direct way to lower your out-of-pocket costs for prescription drugs for eligible patients. The copay cards essentially allow physicians to prescribe medications that are clinically preferred.

Is there a aprepitant Patient Assistance Program (PAP)?

Generic medications like aprepitant do not have PAP savings options. A Patient assistance program, if available would normally be for the brand name version of aprepitant. You can search the brand name of aprepitant and check to see if a co-PAP exists. PAPs are programs that are run and sponsored by pharmaceutical companies. They offer uninsured, insured, or underinsured individuals access to high-cost brand-name medications, which may otherwise be unaffordable.

What should I do if I take too much aprepitant?

Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using aprepitant. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you've used too much aprepitant. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

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What is generic aprepitant?

Generic aprepitant refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of aprepitant

Aprepitant is approved by the U.S. Food and Drug Administration (FDA) for the prevention of chemotherapy-induced nausea and vomiting (CINV).

Active ingredient of aprepitant

The active ingredient of aprepitant is aprepitant.

US brand name of aprepitant and manufacturer

Aprepitant is available in the US under the brand name Emend. The manufacturer of Emend may vary.

UK brand name of aprepitant and manufacturer

In the UK, aprepitant is available under the brand name Emend. The manufacturer of Emend may vary.

Prescription requirement for aprepitant

A prescription (Rx) is required for aprepitant in both the US and the UK.

Availability of aprepitant in the UK with NHS prescription

Aprepitant is available in the UK with an NHS prescription.

Conditions treated by aprepitant

Aprepitant is primarily used for the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients undergoing cancer treatment.

  • Chemotherapy-induced nausea and vomiting (CINV)
  • Post-operative nausea and vomiting (PONV)
  • Radiotherapy-induced nausea and vomiting (RINV)
  • Delayed nausea and vomiting
  • Breakthrough nausea and vomiting
  • Pediatric patients with chemotherapy-induced nausea and vomiting

How does aprepitant work?

Aprepitant belongs to the class of neurokinin-1 receptor antagonist medications. It works by blocking the neurotransmitter substance P in the brain. Substance P plays a role in triggering chemotherapy-induced nausea and vomiting (CINV). By preventing the signals that trigger CINV, aprepitant helps to alleviate these symptoms during treatment. The mechanism of action of aprepitant involves its selective affinity as an antagonist for neurokinin 1 (NK1) receptors. NK1 receptors are found in both the central nervous system and peripheral tissues. Aprepitant’s high affinity for NK1 receptors allows it to effectively block substance P, reducing the occurrence of nausea and vomiting associated with chemotherapy. It is important to note that aprepitant is often given as part of a combination regimen with other antiemetic agents, such as a 5-HT3 receptor antagonist and a corticosteroid like dexamethasone, to provide comprehensive protection against chemotherapy-induced nausea and vomiting.

Forms of aprepitant available

Aprepitant capsules are the most common form of aprepitant. These capsules are taken by mouth, usually once a day, with or without food. They are designed to release the medication slowly into your body, ensuring a steady level of aprepitant in your system. In some cases, aprepitant may be given to you through an intravenous (IV) infusion. This is usually done in a medical setting, such as a hospital or clinic, by a healthcare professional. The injectable form of aprepitant provides a rapid onset of action and is ideal for patients who are unable to take medications orally. Aprepitant is sometimes available in combination packs along with other medications to enhance its effectiveness. These packs may contain aprepitant, a 5-HT3 receptor antagonist (such as ondansetron), and a corticosteroid (such as dexamethasone or methylprednisolone). Using these combination packs can help provide better control of nausea and vomiting for patients undergoing chemotherapy.

Dosage of aprepitant

The dosage of aprepitant may vary depending on the specific chemotherapy regimen and individual patient factors. It is important to follow the recommended dosage instructions provided by the healthcare provider. For the prevention of chemotherapy-induced nausea and vomiting in adults, the recommended dose of aprepitant is 125 mg capsule taken orally one hour before chemotherapy, followed by 80 mg once daily in the morning for the next two days. It is usually used in combination with other antiemetic medications. In pediatric patients aged 6 months and older, the recommended dose of aprepitant for chemotherapy-induced nausea and vomiting is based on body weight.

Directions for aprepitant use

Aprepitant should be taken as directed by the healthcare provider. The specific instructions may include the timing of administration, dosage adjustments, and any necessary precautions. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

What is the pharmacokinetics of aprepitant?

Aprepitant is a medication used to prevent nausea and vomiting associated with chemotherapy. Understanding the pharmacokinetics of a drug is essential in determining its absorption, distribution, metabolism, and elimination from the body.

  • Absorption: Aprepitant is administered orally as a capsule or a suspension. It is well absorbed in the gastrointestinal tract, with peak plasma concentrations achieved within 3 hours after oral administration
  • Distribution: Aprepitant has a high protein-binding capacity, primarily binding to plasma albumin. The volume of distribution is approximately 70 litres, indicating that it is widely distributed throughout the body
  • Metabolism: Aprepitant undergoes extensive metabolism in the liver through the cytochrome P450 enzyme system, mainly CYP3A4. It is primarily metabolized into its active metabolite, aprepitant hydrolysis product (AHP), which also exhibits antiemetic activity. Aprepitant is considered a moderate inhibitor of CYP3A4, which can affect the metabolism of other drugs that are substrates of this enzyme.
  • Elimination: The elimination half-life of aprepitant is approximately 9 to 13 hours. It is primarily excreted in the feces, with minimal renal excretion (less than 1% of the dose). Aprepitant, as well as their metabolites, undergo enterohepatic circulation, which means they are reabsorbed from the intestine and returned to the liver before being eliminated

When taken orally, aprepitant has a bioavailability of approximately 60-65%. This means that about 60-65% of the medication is absorbed into the bloodstream after oral administration. The remaining percentage is either metabolized or eliminated from the body.

Warnings, precautions and contraindications for aprepitant

  • Aprepitant may interact with certain medications, including some commonly used chemotherapy drugs, and dosage adjustments or close monitoring may be necessary
  • Common drugs that may interact with aprepitant include blood thinners like warfarin, benzodiazepines, diltiazem, antibiotics such as clarithromycin and antifungal medications such as ketoconazole and itraconazole
  • It is important to inform the healthcare provider about any existing medical conditions, allergies, and any other medications or supplements you are currently taking, to avoid potential drug interactions and adverse effects
  • Affinity for CYP3A4 enzymes may affect medication metabolism. Coadministration of aprepitant with strong CYP3A4 inducers (eg, rifampin, carbamazepine, phenytoin) may result in a substantial reduction in aprepitant plasma concentrations and decreased efficacy
  • Some individuals may be allergic to aprepitant, resulting in serious reactions. If you notice any signs of an allergic reaction such as rash, itching, swelling, dizziness, or difficulty breathing, seek immediate medical attention and discontinue the use of aprepitant until advised by a healthcare professional
  • Consult your doctor before using aprepitant during pregnancy or breastfeeding
  • The effectiveness of hormonal contraceptives may be reduced if taken at the same time as aprepitant. It is advised to use different forms of birth control

Possible side effects of aprepitant

Common side effects of aprepitant may include tiredness, hiccups, headache, dizziness, constipation, diarrhea, and changes in taste. If these side effects persist or worsen, it is important to contact a healthcare provider.

Similar drugs to aprepitant

Other medications used for the prevention of chemotherapy-induced nausea and vomiting (CINV) include ondansetron, granisetron, and palonosetron.

Sources

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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