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Manufactured by various FDA-approved generic manufacturers.

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Updated on 24 Apr 2024

Learn more about aflibercept

What dosages is aflibercept available in?

What dosages is aflibercept available in?

aflibercept is available as a 2 mg (0.05 mL of 40 mg/mL) solution in a single-dose pre-filled syringe and single-dose vial.

What is aflibercept used for?

What is aflibercept used for?

aflibercept is a VEGF inhibitor and is used for the following:
Wet age-related macular degeneration (wet AMD)
Macular edema following retinal vein occlusion (MEfRVO)
Diabetic retinopathy (DR)
Diabetic macular edema (DME)
Retinopathy of prematurity (ROP)

How does aflibercept work?

How does aflibercept work?

aflibercept is a vascular endothelial growth factor (VEGF) inhibitor. It blocks VEGF, a protein that makes new blood vessels in the body. When there’s too much of these proteins in the eye, it creates new, weak blood vessels which leak fluid into the back of the eye. By blocking VEGF proteins from working, aflibercept slows the growth of additional blood vessels to lessen the amount of fluid leaking in the eye. So it helps to lower the risk of vision loss in different eye conditions.

How do I take aflibercept?

How do I take aflibercept?

aflibercept is dosed as follows:
The dose of aflibercept depends on the condition being treated. In general:


Wet AMD: The typical starting dose is 2 mg into the eye(s) once a month for 3 months. Afterwards, 2 mg once into the eye(s) every 2 months.

MEfRVO: The typical dose is 2 mg into the eye(s) once a month (about every 25 days).

DR and DME: The typical starting dose is 2 mg into the eye(s) once a month for the first 5 months. Afterwards, 2 mg once into the eye(s) every 2 months.


ROP: The typical dose is one 0.4 mg injection into the eye(s). And if needed, your child might receive another injection 10 days after the first injection.

Is it safe for me to take aflibercept?

Is it safe for me to take aflibercept?

aflibercept is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following.
Ocular or periocular infection.
Active intraocular inflammation.

aflibercept Common Side Effects

aflibercept Common Side Effects

  • Common side effects of aflibercept:
  • Cataract
  • Eye pain
  • Raised eye pressure
  • Greater amount of eye floaters
  • Blood spots on the whites of the eye
  • Retinal detachment
aflibercept Serious Side Effects

aflibercept Serious Side Effects

Serious side effects are rare with aflibercept. Contact your healthcare provider immediately if you experience any of the following.

Eye infection (endophthalmitis): eye pain, sensitivity to light, loss of vision, eye redness
Separation of the retina from the back of the eye (retinal detachment): flashing lights, feeling like something is covering your vision, changes in your vision, or vision loss, seeing floaters

Effects of other drugs, drug classes and over-the-counter products on aflibercept

Effects of other drugs, drug classes and over-the-counter products on aflibercept

  • There are no major drug interactions listed for aflibercept. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Who makes aflibercept?

Who makes aflibercept?

Various FDA-approved generic manufacturers

Is aflibercept safe in pregnancy?

Is aflibercept safe in pregnancy?

It is not known if aflibercept will harm your unborn baby. Tell your healthcare provider if you become pregnant while taking aflibercept.


What to do if you missed your aflibercept dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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