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Aflibercept is available as a 2 mg (0.05 mL of 40 mg/mL) solution in a single-dose pre-filled syringe and single-dose vial.

Aflibercept is a VEGF inhibitor and is used for the following:
Wet age-related macular degeneration (wet AMD)
Macular edema following retinal vein occlusion (MEfRVO)
Diabetic retinopathy (DR)
Diabetic macular edema (DME)
Retinopathy of prematurity (ROP)

Aflibercept is a vascular endothelial growth factor (VEGF) inhibitor. It blocks VEGF, a protein that makes new blood vessels in the body. When there’s too much of these proteins in the eye, it creates new, weak blood vessels which leak fluid into the back of the eye. By blocking VEGF proteins from working, Aflibercept slows the growth of additional blood vessels to lessen the amount of fluid leaking in the eye. So it helps to lower the risk of vision loss in different eye conditions.

Aflibercept is dosed as follows:
The dose of Aflibercept depends on the condition being treated. In general:

Adults

Wet AMD: The typical starting dose is 2 mg into the eye(s) once a month for 3 months. Afterwards, 2 mg once into the eye(s) every 2 months.

MEfRVO: The typical dose is 2 mg into the eye(s) once a month (about every 25 days).

DR and DME: The typical starting dose is 2 mg into the eye(s) once a month for the first 5 months. Afterwards, 2 mg once into the eye(s) every 2 months.

Children

ROP: The typical dose is one 0.4 mg injection into the eye(s). And if needed, your child might receive another injection 10 days after the first injection.

Aflibercept is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following.
Ocular or periocular infection.
Active intraocular inflammation.
Hypersensitivity.

• Common side effects of Aflibercept:
• Cataract
• Eye pain
• Raised eye pressure
• Greater amount of eye floaters
• Blood spots on the whites of the eye
• Retinal detachment

Serious side effects are rare with Aflibercept. Contact your healthcare provider immediately if you experience any of the following.

Eye infection (endophthalmitis): eye pain, sensitivity to light, loss of vision, eye redness
Separation of the retina from the back of the eye (retinal detachment): flashing lights, feeling like something is covering your vision, changes in your vision, or vision loss, seeing floaters

• There are no major drug interactions listed for Aflibercept. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

It is not known if Aflibercept will harm your unborn baby. Tell your healthcare provider if you become pregnant while taking Aflibercept.

• Eylea