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Aducanumab is available as a 170 mg/1.7 mL (100 mg/mL) and 300 mg/3 mL (100 mg/mL) single-dose vial.

Aducanumab is an amyloid beta-directed antibody indicated for the treatment of Alzheimer’s disease.

Aducanumab is anti-amyloid monoclonal antibody. It specifically targets a protein in the brain called beta-amyloid. In Alzheimer’s disease, these proteins clump together to form plaques. Aducanumab lowers the amount of beta-amyloid plaques in the brain. This suggests, but doesn’t show, Aducanumab can help slow Alzheimer’s from getting worse. More studies are needed to confirm whether or not fewer plaques actually means slower disease progression.

Titration is required for treatment initiation of Aducanumab. The recommended maintenance dosage is 10 mg/kg administered as an intravenous infusion over approximately one hour every four weeks.

Aducanumab is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Aducanumab:

• Swelling in the brain
• Headache
• Small brain bleed
• Deposits in the brain due to bleeding that can cause hearing loss or gait and balance issues
• Falling
• Diarrhea
• Confusion

Serious side effects are rare with Aducanumab. Contact your healthcare provider immediately if you experience any of the following:

• Brain swelling or bleeding: headache, dizziness, nausea, confusion, or vision changes
• Allergic reaction: hives (urticaria) or swelling of the lips, mouth, and throat

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Aduhelm