Paliperidone Palmitate - Save Up to 90% with Coupons, Discounts & Assistance Programs

Paliperidone Palmitate is available as a 1.5 mg, 3 mg, 6 mg, and 9 mg extended-release tablet.

Paliperidone Palmitate is an atypical antipsychotic and is used to treat schizophrenia and schizoaffective disorder.

Paliperidone Palmitate is an atypical antipsychotic. It affects dopamine and serotonin levels in your brain, which helps to control your thoughts, mood, and behaviors.

Paliperidone Palmitate is typically dosed as 6 mg by mouth once daily. The typical dosing range is 3 mg to 12 mg once daily.
Your dose might differ if you’re an older adult or if you have kidney problems.

Paliperidone Palmitate is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known hypersensitivity to paliperidone, risperidone, or to any excipients in Paliperidone Palmitate.

Common side effects of Paliperidone Palmitate include:

• Abnormal muscle movements
• Drowsiness
• Headache
• Irregular heart beat
• Vomiting
• Anxiety

Serious side effects are rare with Paliperidone Palmitate. Contact your healthcare provider immediately if you experience any of the following.

• Neuroleptic malignant syndrome: high fever, muscle stiffness, confusion, sweating, changes in pulse, heart rate, changes in blood pressure
• Tardive dyskinesia: uncontrolled muscle movements, such as facial grimacing, lip-smacking, blinking
• Extremely high blood sugar levels: feeling very hungry or thirsty, urinating more often, stomach pain, weakness, fruity-smelling breath
• Priapism: painful erection that that lasts longer than 4 hours
• Difficulty swallowing
• Seizures

The following medications may interact with Paliperidone Palmitate:

• Centrally-acting drugs: Due to CNS effects, use caution in combination. Avoid alcohol
• Drugs that may cause orthostatic hypotension: An additive effect may be observed when co-administered with Paliperidone Palmitate
• Strong CYP3A4/P-glycoprotein (P-gp) inducers: It may be necessary to increase the dose of Paliperidone Palmitate when a strong inducer of both CYP3A4 and P-gp (e.g., carbamazepine) is co-administered. Conversely, on discontinuation of the strong inducer, it may be necessary to decrease the dose of Paliperidone Palmitate
• Co-administration of divalproex sodium: Increased Cmax and AUC of paliperidone by approximately 50%. Adjust dose of Paliperidone Palmitate if necessary based on clinical assessment

Various FDA-approved generic manufacturers

Paliperidone Palmitate may cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure. Talk with your doctor before starting this medication if you are or become pregnant. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Paliperidone Palmitate, during pregnancy. Healthcare providers are encouraged to register patients by contacting the National Pregnancy Registry for Atypical 33 Antipsychotics at 1-866-961-2388 or online at  women’s mental health

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