Used for Schizophrenia

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Programs are suitable for individuals who want to buy INVEGA SUSTENNA without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Janssen Pharmaceuticals

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about INVEGA SUSTENNA



INVEGA SUSTENNA is the brand name for paliperidone palmitate and is available as an extended-release injectable

What dosages is INVEGA SUSTENNA available in?

What dosages is INVEGA SUSTENNA available in?

INVEGA SUSTENNA is available as 39 mg/0.25 mL, 78 mg/0.5 mL, 117 mg/0.75 mL, 156 mg/mL, or 234 mg/1.5 mL extended-release injectable suspension.

What is INVEGA SUSTENNA used for?

What is INVEGA SUSTENNA used for?

INVEGA SUSTENNA is an atypical antipsychotic used for the following:

  • Schizophrenia
  • Schizoaffective disorder
How does INVEGA SUSTENNA work?

How does INVEGA SUSTENNA work?

INVEGA SUSTENNA is an atypical antipsychotic. It can affect dopamine and serotonin levels in your brain, which helps control your thoughts, mood, and behaviors.



INVEGA SUSTENNA is given as an injection into the muscle (IM) by a healthcare provider. Your provider will determine your dose based on how you respond to the medication. The typical dosing schedule of INVEGA SUSTENNA is outlined below:


  • Day 1: 234 mg
  • Day 8: 156 mg
  • Maintenance dose: The typical maintenance dose is 39-234 mg monthly, starting 5 weeks after the first injection

Schizoaffective disorder:

  • Day 1: 234 mg
  • Day 8: 156 mg
  • Maintenance dose: The typical maintenance dose is 78-234 mg monthly, starting 5 weeks after the first injection
Is it safe for me to take INVEGA SUSTENNA?

Is it safe for me to take INVEGA SUSTENNA?

INVEGA SUSTENNA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have an allergy to paliperidone (Invega) or risperidone (Risperdal).

INVEGA SUSTENNA Common Side Effects

INVEGA SUSTENNA Common Side Effects

Common side effects of INVEGA SUSTENNA:

  • Headache
  • Agitation
  • Injection site reactions
  • Anxiety
  • Sleepiness
  • Dizziness
  • Not able to stay still
INVEGA SUSTENNA Serious Side Effects

INVEGA SUSTENNA Serious Side Effects

Serious side effects are rare with INVEGA SUSTENNA. Contact your healthcare provider immediately if you experience any of the following.

  • Seizures
  • Difficulty swallowing
  • Neuroleptic malignant syndrome: high fever, muscle stiffness, confusion, sweating, changes in pulse, heart rate, changes in blood pressure
  • Tardive dyskinesia: uncontrolled muscle movements, such as facial grimacing, lip-smacking, blinking
  • Extremely high blood sugar levels: feeling very hungry or thirsty, urinating more often, stomach pain, weakness, fruity-smelling breath
  • Serious infections: fever, chills, body aches, tiredness, cough
  • Priapism: painful erection that that lasts longer than 4 hours
Effects of other drugs, drug classes and over-the-counter products on INVEGA SUSTENNA

Effects of other drugs, drug classes and over-the-counter products on INVEGA SUSTENNA

The following medications may interact with INVEGA SUSTENNA:

  • Drugs that may cause orthostatic hypotension: An additive effect may occur when co-administered with INVEGASUSTENNA
  • Strong CYP3A4/P-glycoprotein (P-gp) inducers: Avoid using a strong inducer of CYP3A4 and/or P-gp (e.g., carbamazepine, rifampin, St John’s Wort) during a dosing interval for INVEGA SUSTENNA. If administering a strong inducer is necessary, consider managing the patient using paliperidone extended release tablets


Janssen Pharmaceuticals

Is INVEGA SUSTENNA safe in pregnancy?

Is INVEGA SUSTENNA safe in pregnancy?

INVEGA SUSTENNA may cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to atypical antipsychotics, including INVEGA SUSTENNA, during pregnancy. Healthcare providers are encouraged to register patients by contacting the National Pregnancy Registry for Atypical Antipsychotics at 1-866-961-2388 or online at women’s health 


What to do if you missed your INVEGA SUSTENNA dose

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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