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Invega Trinza is the brand name for paliperidone palmitate and is available as an extended-release injectable suspension.

Invega Trinza is available as a 273 mg/0.88 mL, 410 mg/1.32 mL, 546 mg/1.75 mL, or 819 mg/2.63 mL extended-release injectable suspension.

• Invega Trinza is an atypical antipsychotic and is used to treat schizophrenia

Invega Trinza is an atypical antipsychotic. It can affect dopamine and serotonin levels in your brain, which helps control your thoughts, mood, and behaviors.

• Invega Trinza is given as an injection into the muscle by a healthcare provider. It should only be used after you’ve taken Invega Sustenna (paliperidone) for at least 4 months. Your provider will determine your dose based on what dose of Invega Sustenna (paliperidone) you were taking
• You’ll receive your first dose of Invega Trinza when your next 1-month Invega Sustenna (paliperidone) dose is due. After that, Invega Trinza is injected once every 3 months. The typical dose ranges from 273 mg to 819 mg

Invega Trinza is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have an allergy to paliperidone (Invega) or risperidone (Risperdal).

Common side effects of Invega Trinza:

• Upper respiratory tract infection
• Weight gain
• Headache
• Not able to stay still

Serious side effects are rare with Invega Trinza.Contact your healthcare provider immediately if you experience any of the following.

• Seizures
• Difficulty swallowing
• Neuroleptic malignant syndrome: high fever, muscle stiffness, confusion, sweating, changes in pulse, heart rate, changes in blood pressure
• Tardive dyskinesia: uncontrolled muscle movements, such as facial grimacing, lip-smacking, blinking
• Extremely high blood sugar levels: feeling very hungry or thirsty, urinating more often, stomach pain, weakness, fruity-smelling breath
• Serious infections: fever, chills, body aches, tiredness, cough
• Priapism: painful erection that that lasts longer than 4 hours

The following medications may interact with Invega Trinza:

• Strong CYP3A4/P-glycoprotein (P-gp) inducers: Avoid using a strong inducer of CYP3A4 and/or P-gp (e.g., carbamazepine, rifampin, St John’s Wort) during a dosing interval for Invega Trinza. If administering a strong inducer is necessary, consider managing the patient using paliperidone extended release tablets

Janssen Pharmaceuticals

Invega Trinza may cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to atypical antipsychotics, including Invega Trinza, during pregnancy. Healthcare providers are encouraged to register patients by contacting the National Pregnancy Registry for Atypical Antipsychotics at 1-866-961-2388 or online at women’s health

• Paliperidone Palmitate