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Vortioxetine is available as 5 mg, 10 mg, and 20 mg oral tablet.

Vortioxetine is an atypical antidepressant and is used to treat depression.

Vortioxetine is an atypical antidepressant. Although it’s not fully understood, it seems to work by boosting the action of serotonin in your brain. Serotonin is a neurotransmitter (communication molecule) that’s associated with well-being and happiness.

Vortioxetine is typically started at 10 mg by mouth once daily. The maximum dose is 20 mg by mouth per day.

• Your dose will depend on what other medications you’re taking and how you respond to Vortioxetine

Vortioxetine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Vortioxetine will not be safe for you to take. Taking a monoamine oxidase inhibitor (MAOI) within 21 days of Vortioxetine.

Common side effects of Vortioxetine:

• Nausea
• Diarrhea
• Dizziness
• Dry mouth
• Vomiting
• Constipation

Serious side effects are rare with Vortioxetine. Contact your healthcare provider immediately if you experience any of the following.

• Suicidal thoughts and behavior
• Serotonin syndrome: fast heart rate, sweating, muscle stiffness or spasms, fever, confusion
• Very low levels of sodium (hyponatremia): nausea, vomiting, headache, memory problems, confusion, muscle weakness or cramps, low blood pressure
• Serious bleeding: dizziness, pale skin, feeling weak, bleeding that’s difficult to stop, bruising that won’t go away, vomiting blood, black and tarry stool

The following medications may interact with Vortioxetine:

• Strong inhibitors of CYP2D6: Reduce Vortioxetine dose by half when a strong CYP2D6 inhibitor (e.g., bupropion, fluoxetine paroxetine, or quinidine) is coadministered
• Strong CYP Inducers: Consider increasing Vortioxetine dose when a strong CYP inducer (e.g., rifampin, carbamazepine, or phenytoin) is coadministered for more than 14 days. The maximum recommended dose should not exceed 3 times the original dose

Various FDA-approved generic manufacturers

It is not known if Vortioxetine will harm your unborn baby. Taking Vortioxetine while pregnant in your third trimester may cause your newborn baby to have withdrawal symptoms that causes a certain type of breathing problem called Persistent Pulmonary Hypertension of the Newborn (PPHN).

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