TRINTELLIX
Used for Depression
NowPatient helps you obtain your TRINTELLIX prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by Takeda Pharmaceuticals
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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TRINTELLIX key facts
What is TRINTELLIX?
TRINTELLIX is the brand name for vortioxetine and is available as an oral tablet.
What dosages is TRINTELLIX available in?
TRINTELLIX is available as 5 mg, 10 mg, and 20 mg oral tablet.
What is TRINTELLIX used for?
TRINTELLIX is an atypical antidepressant and is used to treat depression.
How does TRINTELLIX work?
TRINTELLIX is an atypical antidepressant. Although it’s not fully understood, it seems to work by boosting the action of serotonin in your brain. Serotonin is a neurotransmitter (communication molecule) that’s associated with well-being and happiness.
How do I take TRINTELLIX?
TRINTELLIX is typically started at 10 mg by mouth once daily. The maximum dose is 20 mg by mouth per day.
- Your dose will depend on what other medications you’re taking and how you respond to TRINTELLIX
Is it safe for me to take TRINTELLIX?
TRINTELLIX is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because TRINTELLIX will not be safe for you to take. Taking a monoamine oxidase inhibitor (MAOI) within 21 days of TRINTELLIX.
TRINTELLIX Common Side Effects
Common side effects of TRINTELLIX:
- Nausea
- Diarrhea
- Dizziness
- Dry mouth
- Vomiting
- Constipation
TRINTELLIX Serious Side Effects
Serious side effects are rare with TRINTELLIX. Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts and behavior
- Serotonin syndrome: fast heart rate, sweating, muscle stiffness or spasms, fever, confusion
- Very low levels of sodium (hyponatremia): nausea, vomiting, headache, memory problems, confusion, muscle weakness or cramps, low blood pressure
- Serious bleeding: dizziness, pale skin, feeling weak, bleeding that’s difficult to stop, bruising that won’t go away, vomiting blood, black and tarry stool
Effects of other drugs, drug classes and over-the-counter products on TRINTELLIX
The following medications may interact with TRINTELLIX:
- Strong inhibitors of CYP2D6: Reduce TRINTELLIX dose by half when a strong CYP2D6 inhibitor (e.g., bupropion, fluoxetine paroxetine, or quinidine) is coadministered
- Strong CYP Inducers: Consider increasing TRINTELLIX dose when a strong CYP inducer (e.g., rifampin, carbamazepine, or phenytoin) is coadministered for more than 14 days. The maximum recommended dose should not exceed 3 times the original dose
Who makes TRINTELLIX?
Takeda Pharmaceuticals
Is TRINTELLIX safe in pregnancy?
It is not known if TRINTELLIX will harm your unborn baby. Taking TRINTELLIX while pregnant in your third trimester may cause your newborn baby to have withdrawal symptoms that causes a certain type of breathing problem called Persistent Pulmonary Hypertension of the Newborn (PPHN).
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my TRINTELLIX prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your TRINTELLIX prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient TRINTELLIX savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient TRINTELLIX savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for TRINTELLIX | Canadian Prescription Savings* for TRINTELLIX | TRINTELLIX Drug Coupon* | TRINTELLIX Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of TRINTELLIX?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for TRINTELLIX | Canadian Prescription Savings* for TRINTELLIX | TRINTELLIX Drug Coupon* | TRINTELLIX Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the TRINTELLIX savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the TRINTELLIX drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for TRINTELLIX, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the TRINTELLIX prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, TRINTELLIX is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed TRINTELLIX for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the TRINTELLIX prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the TRINTELLIX prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for TRINTELLIX
If you are having trouble paying for your TRINTELLIX medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for TRINTELLIX you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- TRINTELLIX is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers TRINTELLIX
- If TRINTELLIX is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for TRINTELLIX
If you are having trouble paying for your TRINTELLIX medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for TRINTELLIX you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers TRINTELLIX
- If TRINTELLIX is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for TRINTELLIX
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your TRINTELLIX treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for TRINTELLIX you will need to meet the following criteria:
- You must be currently insured and have coverage for TRINTELLIX
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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