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Trintellix is the brand name for vortioxetine and is available as an oral tablet.

Trintellix is available as 5 mg, 10 mg, and 20 mg oral tablet.

Trintellix is an atypical antidepressant and is used to treat depression.

Trintellix is an atypical antidepressant. Although it’s not fully understood, it seems to work by boosting the action of serotonin in your brain. Serotonin is a neurotransmitter (communication molecule) that’s associated with well-being and happiness.

Trintellix is typically started at 10 mg by mouth once daily. The maximum dose is 20 mg by mouth per day.

• Your dose will depend on what other medications you’re taking and how you respond to Trintellix

Trintellix is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Trintellix will not be safe for you to take. Taking a monoamine oxidase inhibitor (MAOI) within 21 days of Trintellix.

Common side effects of Trintellix:

• Nausea
• Diarrhea
• Dizziness
• Dry mouth
• Vomiting
• Constipation

Serious side effects are rare with Trintellix. Contact your healthcare provider immediately if you experience any of the following.

• Suicidal thoughts and behavior
• Serotonin syndrome: fast heart rate, sweating, muscle stiffness or spasms, fever, confusion
• Very low levels of sodium (hyponatremia): nausea, vomiting, headache, memory problems, confusion, muscle weakness or cramps, low blood pressure
• Serious bleeding: dizziness, pale skin, feeling weak, bleeding that’s difficult to stop, bruising that won’t go away, vomiting blood, black and tarry stool

The following medications may interact with Trintellix:

• Strong inhibitors of CYP2D6: Reduce Trintellix dose by half when a strong CYP2D6 inhibitor (e.g., bupropion, fluoxetine paroxetine, or quinidine) is coadministered
• Strong CYP Inducers: Consider increasing Trintellix dose when a strong CYP inducer (e.g., rifampin, carbamazepine, or phenytoin) is coadministered for more than 14 days. The maximum recommended dose should not exceed 3 times the original dose

Takeda Pharmaceuticals

It is not known if Trintellix will harm your unborn baby. Taking Trintellix while pregnant in your third trimester may cause your newborn baby to have withdrawal symptoms that causes a certain type of breathing problem called Persistent Pulmonary Hypertension of the Newborn (PPHN).

• Vortioxetine