PREMPHASE
Used for Menopause
Are you tired of high medication costs? Our service offers unbeatable savings on your PREMPHASE prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by Pfizer
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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PREMPHASE key facts
What is PREMPHASE?
PREMPHASE is the brand name for conjugated estrogens/medroxyprogesterone acetate and is available as an oral tablet.
What dosages is PREMPHASE available in?
PREMPHASE is available as an oral tablet that contains 0.625 mg CE and 0.625 mg CE plus 5 mg MPA.
What is PREMPHASE used for?
PREMPHASE is an estrogen replacement / progestin and is used for the following:
- Hot flashes, night sweats, and flushes caused by menopause
- Vaginal dryness and burning caused by menopause
- Prevention of postmenopausal osteoporosis (not a first-choice)
How does PREMPHASE work?
PREMPHASE is a combination of two medications. Conjugated estrogens is a mixture of estrogens that replaces the estrogen your body loses during menopause. It relieves hot flashes, relieves vaginal dryness, and strengthens bones. Medroxyprogesterone is a progestin that protects the uterus from damage and helps prevent uterine cancer.
How do I take PREMPHASE?
PREMPHASE: There are 2 different colored tablets in the package. Take 1 dark red tablet by mouth once daily on days 1 through 14. Take 1 light blue tablet by mouth once daily on days 15 through 28. The dark-red tablet contains 0.625 mg of conjugated estrogens only, and the light blue tablet contains 0.625 mg conjugated estrogens and 5 mg of medroxyprogesterone.
Is it safe for me to take PREMPHASE?
PREMPHASE is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of the following apply:
- Undiagnosed abnormal genital bleeding
- Known, suspected, or history of breast cancer
- Known or suspected estrogen-dependent neoplasia
- Active DVT, PE, or a history of these conditions
- Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
- Known anaphylactic reaction or angioedema to PREMPRO/PREMPHASE
- Known liver dysfunction or disease
- Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders
- Known or suspected pregnancy
PREMPHASE Common Side Effects
Common side effects of PREMPHASE:
- Breast pain
- Headaches
- Stomach pain
- Menstrual cramps
- Gas
- Nausea
- Depression
- More vaginal discharge than usual
PREMPHASE Serious Side Effects
Serious side effects are rare with PREMPHASE. Contact your healthcare provider immediately if you experience any of the following.
- Allergic reactions
- Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
- Stroke: sudden trouble talking, trouble walking, or numbness on one side of your body or face
- Shortness of breath
- Sudden, severe headaches
- Breast lumps or pain
- Unusual or heavy vaginal bleeding
Effects of other drugs, drug classes and over-the-counter products on PREMPHASE
The following medications may interact with PREMPHASE:
- Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism
- Aminoglutethimide administered concomitantly with MPA may significantly depress the bioavailability of medroxyprogesterone acetate
Who makes PREMPHASE?
Pfizer
Is PREMPHASE safe in pregnancy?
PREMPRO and PREMPHASE should not be used during pregnancy.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my PREMPHASE prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your PREMPHASE prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient PREMPHASE savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient PREMPHASE savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for PREMPHASE | Canadian Prescription Savings* for PREMPHASE | PREMPHASE Drug Coupon* | PREMPHASE Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of PREMPHASE?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for PREMPHASE | Canadian Prescription Savings* for PREMPHASE | PREMPHASE Drug Coupon* | PREMPHASE Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the PREMPHASE savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the PREMPHASE drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for PREMPHASE, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the PREMPHASE prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, PREMPHASE is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed PREMPHASE for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the PREMPHASE prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the PREMPHASE prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for PREMPHASE
If you are having trouble paying for your PREMPHASE medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for PREMPHASE you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- PREMPHASE is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers PREMPHASE
- If PREMPHASE is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for PREMPHASE
If you are having trouble paying for your PREMPHASE medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for PREMPHASE you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers PREMPHASE
- If PREMPHASE is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for PREMPHASE
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your PREMPHASE treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for PREMPHASE you will need to meet the following criteria:
- You must be currently insured and have coverage for PREMPHASE
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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