Home
/
Medications
/
PREMPHASE

PREMPHASE

Used for Menopause

View PREMPHASE savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or PREMPHASE Patient Assistance Program.

Programs are suitable for individuals who want to buy PREMPHASE without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Pfizer

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

Drug savings programs

  • Qualified

    Rx Advantage Card

    A hand holding a dark-colored prescription savings card with various ID numbers and the label "Rx Advantage." Text below states the card is not insurance and cannot be used for Medicare or Medicaid.

    Save up to 90%

  • Unavailable

    Canadian Prescription Savings

    N/A
    Manufactured by
    N/A
    Powered by
    Prescription Help Logo
    Unavailable
  • Unavailable

    Drug Coupons

    A hand holds a Copay Savings Card that states eligible patients with commercial insurance may pay as little as $0 per tube for Opzelura.
    Unavailable
  • Available

    Patient Assistance Programs

    A picture of a patient assistance application form

    FREE

scrollable
Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about PREMPHASE

What is PREMPHASE?

What is PREMPHASE?

PREMPHASE is the brand name for conjugated estrogens/medroxyprogesterone acetate and is available as an oral tablet.

What dosages is PREMPHASE available in?

What dosages is PREMPHASE available in?

PREMPHASE is available as an oral tablet that contains 0.625 mg CE and 0.625 mg CE plus 5 mg MPA.

What is PREMPHASE used for?

What is PREMPHASE used for?

PREMPHASE is an estrogen replacement / progestin and is used for the following:

  • Hot flashes, night sweats, and flushes caused by menopause
  • Vaginal dryness and burning caused by menopause
  • Prevention of postmenopausal osteoporosis (not a first-choice)
How does PREMPHASE work?

How does PREMPHASE work?

PREMPHASE is a combination of two medications. Conjugated estrogens is a mixture of estrogens that replaces the estrogen your body loses during menopause. It relieves hot flashes, relieves vaginal dryness, and strengthens bones. Medroxyprogesterone is a progestin that protects the uterus from damage and helps prevent uterine cancer.

How do I take PREMPHASE?

How do I take PREMPHASE?

PREMPHASE: There are 2 different colored tablets in the package. Take 1 dark red tablet by mouth once daily on days 1 through 14. Take 1 light blue tablet by mouth once daily on days 15 through 28. The dark-red tablet contains 0.625 mg of conjugated estrogens only, and the light blue tablet contains 0.625 mg conjugated estrogens and 5 mg of medroxyprogesterone.

Is it safe for me to take PREMPHASE?

Is it safe for me to take PREMPHASE?

PREMPHASE is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of the following apply:

  • Undiagnosed abnormal genital bleeding
  • Known, suspected, or history of breast cancer
  • Known or suspected estrogen-dependent neoplasia
  • Active DVT, PE, or a history of these conditions
  • Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
  • Known anaphylactic reaction or angioedema to PREMPRO/PREMPHASE
  • Known liver dysfunction or disease
  • Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders
  • Known or suspected pregnancy
PREMPHASE Common Side Effects

PREMPHASE Common Side Effects

Common side effects of PREMPHASE:

  • Breast pain
  • Headaches
  • Stomach pain
  • Menstrual cramps
  • Gas
  • Nausea
  • Depression
  • More vaginal discharge than usual
PREMPHASE Serious Side Effects

PREMPHASE Serious Side Effects

Serious side effects are rare with PREMPHASE. Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reactions
  • Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
  • Stroke: sudden trouble talking, trouble walking, or numbness on one side of your body or face
  • Shortness of breath
  • Sudden, severe headaches
  • Breast lumps or pain
  • Unusual or heavy vaginal bleeding
Effects of other drugs, drug classes and over-the-counter products on PREMPHASE

Effects of other drugs, drug classes and over-the-counter products on PREMPHASE

The following medications may interact with PREMPHASE:

  • Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism
  • Aminoglutethimide administered concomitantly with MPA may significantly depress the bioavailability of medroxyprogesterone acetate
Who makes PREMPHASE?

Who makes PREMPHASE?

Pfizer

Is PREMPHASE safe in pregnancy?

Is PREMPHASE safe in pregnancy?

PREMPRO and PREMPHASE should not be used during pregnancy.

pill

What to do if you missed your PREMPHASE dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
dollar sign

Drug Savings Tips

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

FAQ logo

People Asked

Now Patient Data Security

Data Security

Our Commitment to You.

Find out moreNow Patient Data SecurityNow Patient Data Security

What is NowPatient

Telehealth and Online Pharmacy

NowPatient is a licensed online pharmacy and doctor service that is available around the world. Our service is FREE and packed with valuable features that can benefit your health such as medication reminders, educational blogs, medically approved symptoms checker, UK NHS online pharmacyprivate treatment plansRx Advantage cardhealth conditions information, affordable medications options, genetic testinghome test kitshealth riskspollen meterair quality monitor, weight loss plans, drug savings programs and lots more!

A laptop screen displaying a health dashboard with widgets showing health profile, notifications, personalized health tools, and favorite widgets including body mass index and weight loss tracking.

WHY WE BUILT NOWPATIENT

To improve the lives of everyone by making high-quality care accessible and convenient

We are here to improve lives. Our service gives you access to smart features and resources that can help empower you to take control of your health and improve your health outcomes. All this, in one place, for FREE. We strive to bring a fresh perspective to managing health. NowPatient can be accessed by downloading the App or using your web browser.

Download our app today

A collage showing a map with pharmacies, a questionnaire, medication details, and a person video chatting on a screen.

Can I trust NowPatient

Meet our medical team

We are a passionate group of clinicians and medical writers covering a broad range of specialities with experience operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process

Your Questions Answered

For your peace of mind, we can answer your questions quickly

We have a comprehensive list of FAQ’s on each feature page. Alternatively, for broader questions around our service just click the button below.
Find your answers