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Conjugated Estrogens Plus Medroxyprogesterone Acetate is available as an oral tablet that contains 0.625 mg CE and 0.625 mg CE plus 5 mg MPA.

Conjugated Estrogens Plus Medroxyprogesterone Acetate is an estrogen replacement / progestin and is used for the following:

• Hot flashes, night sweats, and flushes caused by menopause
• Vaginal dryness and burning caused by menopause
• Prevention of postmenopausal osteoporosis (not a first-choice)

Conjugated Estrogens Plus Medroxyprogesterone Acetate is a combination of two medications. Conjugated estrogens is a mixture of estrogens that replaces the estrogen your body loses during menopause. It relieves hot flashes, relieves vaginal dryness, and strengthens bones. Medroxyprogesterone is a progestin that protects the uterus from damage and helps prevent uterine cancer.

Conjugated Estrogens Plus Medroxyprogesterone Acetate: There are 2 different colored tablets in the package. Take 1 dark red tablet by mouth once daily on days 1 through 14. Take 1 light blue tablet by mouth once daily on days 15 through 28. The dark-red tablet contains 0.625 mg of conjugated estrogens only, and the light blue tablet contains 0.625 mg conjugated estrogens and 5 mg of medroxyprogesterone.

Conjugated Estrogens Plus Medroxyprogesterone Acetate is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of the following apply:

• Undiagnosed abnormal genital bleeding
• Known, suspected, or history of breast cancer
• Known or suspected estrogen-dependent neoplasia
• Active DVT, PE, or a history of these conditions
• Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
• Known anaphylactic reaction or angioedema to PREMPRO/Conjugated Estrogens Plus Medroxyprogesterone Acetate
• Known liver dysfunction or disease
• Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders
• Known or suspected pregnancy

Common side effects of Conjugated Estrogens Plus Medroxyprogesterone Acetate:

• Breast pain
• Headaches
• Stomach pain
• Menstrual cramps
• Gas
• Nausea
• Depression
• More vaginal discharge than usual

Serious side effects are rare with Conjugated Estrogens Plus Medroxyprogesterone Acetate. Contact your healthcare provider immediately if you experience any of the following.

• Allergic reactions
• Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
• Stroke: sudden trouble talking, trouble walking, or numbness on one side of your body or face
• Shortness of breath
• Sudden, severe headaches
• Breast lumps or pain
• Unusual or heavy vaginal bleeding

The following medications may interact with Conjugated Estrogens Plus Medroxyprogesterone Acetate:

• Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism
• Aminoglutethimide administered concomitantly with MPA may significantly depress the bioavailability of medroxyprogesterone acetate

Various FDA-approved generic manufacturers

PREMPRO and Conjugated Estrogens Plus Medroxyprogesterone Acetate should not be used during pregnancy.

• Premphase