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Insulin Lispro Protamine/Insulin Lispro is available as a subcutaneous injection that contains 100 units/mL (U-100), 50% insulin lispro protamine and 50% insulin lispro.

HUMALOG MIX 50/50 is an insulin and is used for the following:

• Type 1 diabetes
• Type 2 diabetes

HUMALOG MIX 50/50 releases a hormone called insulin into the body to lower glucose (sugar) levels in the blood.

• Inject Insulin Lispro Protamine/Insulin Lispro subcutaneously (within 15 minutes before a meal) in abdominal wall, thigh, upper arm, or buttocks and rotate injection sites to reduce the risk of lipodystrophy and localized cutaneous amyloidosis
• Individualize and adjust dosage based on metabolic needs, blood glucose monitoring results and glycemic control goal

HUMALOG MIX 50/50 is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have symptoms of hypoglycemia (low blood sugar).

Common side effects of HUMALOG MIX 50/50:

• Low blood sugar
• Injection site reaction (e.g., redness, swelling, itching)
• Changes in skin shape at the site of the injection
• Weight gain
• Swelling in the hands and feet
• Itching
• Rash

Serious side effects are rare with HUMALOG MIX 50/50. Contact your healthcare provider immediately if you experience any of the following.

• Severe hypoglycemia (dangerously low blood sugar): if not treated, severe hypoglycemia can lead to unconsciousness, seizures, and even death
• Severe allergic reactions: rash, hives, swelling of face, tongue, and throat, difficulty breathing
• Dangerously low levels of potassium: if not treated, it can lead to difficulty breathing, irregular heartbeat, and even death

The following medications may interact with HUMALOG MIX 50/50:

• Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g. octreotide), and sulfonamide antibiotics
• Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics, corticosteroids, danazol, diuretics estrogens, glucagon, isoniazid, niacin, oral contraceptives
• phenothiazines, progestogens (e.g., in oral contraceptives) protease inhibitors, somatropin, sympathomimetic agents (e.g. albuterol, epinephrine, terbutaline), and thyroid hormones
• Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine
• Drugs that may blunt the signs and symptoms of hypoglycemia: beta-blockers, clonidine, guanethidine, and reserpine

Various FDA-approved generic manufacturers

Published studies with Insulin Lispro Protamine/Insulin Lispro used during pregnancy have not reported an association between insulin lispro and the induction of major birth defects, miscarriage, or adverse maternal or fetal outcomes. If you become pregnant while receiving Insulin Lispro Protamine/Insulin Lispro, talk to your healthcare provider.

• Humalog Mix 50/50
• Humalog Mix 75/25