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HUMALOG MIX 75/25 is the brand name for insulin lispro protamine and insulin lispro and is available as a subcutaneous injection.

Humalog Mix 75/25 is available as a subcutaneous injection that contains 100 units/mL (U-100), 75% insulin lispro protamine and 25% insulin lispro.

HUMALOG MIX 75/25 is an insulin and is used for the following:

• Type 1 diabetes
• Type 2 diabetes

HUMALOG MIX 75/25 is an insulin. Insulin is a natural hormone your body normally makes to lower glucose (sugar) levels in the blood. It helps your body absorb and store sugar and fat from your bloodstream after eating a meal.

• The dose of Humalog Mix 75/25 will be different for each person. The dose depends on whether you’re using it for type 1 diabetes or type 2 diabetes, your weight, how well you respond to insulin, and your blood sugar levels Please follow the directions from your provider carefully.
• Humalog Mix 75/25 is typically dosed twice a day (with each dose meant to cover 2 meals or a meal and a snack). It should be injected under the skin within 15 minutes before a meal

HUMALOG MIX 75/25 is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have symptoms of hypoglycemia.

Common side effects of HUMALOG MIX 75/25:

• Low blood sugar (hypoglycemia)
• Allergic reactions
• Injection site reaction (e.g., redness, swelling, itching)
• Changes in skin shape at the site of the injection
• Weight gain
• Swelling (edema)
• Itching
• Rash

Serious side effects are rare with HUMALOG MIX 75/25. Contact your healthcare provider immediately if you experience any of the following.

• Severe hypoglycemia (dangerously low blood sugar): if not treated, severe hypoglycemia can lead to unconsciousness, seizures, and even death
• Severe allergic reactions: rash, hives, swelling of face, tongue, and throat, difficulty breathing
• Dangerously low levels of potassium: if not treated, it can lead to difficulty breathing, irregular heartbeat, and even death

The following medications may interact with HUMALOG MIX 75/25:

• Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors
• pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g. octreotide), and sulfonamide antibiotics
• Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics, corticosteroids, danazol, diuretics estrogens, glucagon, isoniazid, niacin, oral contraceptives phenothiazines, progestogens (e.g., in oral contraceptives) protease inhibitors, somatropin, sympathomimetic agents (e.g. albuterol, epinephrine, terbutaline), and thyroid hormones
• Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine.
• Drugs that may blunt the signs and symptoms of hypoglycemia: beta-blockers, clonidine, guanethidine, and reserpine

Eli Lilly and Company

Published studies with Humalog Mix 75/25 used during pregnancy have not reported an association between insulin lispro and the induction of major birth defects, miscarriage, or adverse maternal or fetal outcomes. If you become pregnant while receiving Humalog Mix 75/25, talk to your healthcare provider.

• Insulin Lispro Protamine/Insulin Lispro