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Hylan G-F 20 is available as an intraarticular injection.

Hylan G-F 20 is a viscoelastic used to treat pain due to osteoarthritis of the knee.

Hylan G-F 20 is a viscoelastic. It’s similar to a substance that’s naturally found in the connective tissues in your body. When it’s injected into the knee, it helps lubricate your knee joint so that you can move it smoothly. This can reduce pain from osteoarthritis in your knee.

Hylan G-F 20 is injected intraarticularly into your knee once weekly for 1 to 5 weeks.

Hylan G-F 20 is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Do not administer to patients with known hypersensitivity (allergy) to hyaluronan (sodium hyaluronate) preparations. Do not inject SYNVISC-ONE in the knees of patients having knee joint infections or skin diseases or infections in the area of the injection site.

Common side effects of Hylan G-F 20:

• Joint pain and swelling
• Back pain
• Muscle and bone pain
• Injection site reaction (redness, swelling)

Serious side effects are rare with Hylan G-F 20. Contact your healthcare provider immediately if you experience any of the following.

• Severe allergic reaction: rash, trouble breathing, swelling of lips, tongue, or throat

• There are no major drug interactions listed for Hylan G-F 20. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Various FDA-approved generic manufacturers

It is not known if Hylan G-F 20 will harm your unborn baby. Tell your healthcare provider if you are pregnant or plan to become pregnant while using Hylan G-F 20.

• Synvisc
• Synvisc One