alteplase
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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You can lower cost of your alteplase using one of the 4 following drug savings programs
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alteplase Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is alteplase available in?
alteplase is available in in vials that contains 2.2 mg of alteplase.
What is alteplase used for?
alteplase is a tissue plasminogen activator (tPA) indicated for the restoration of function to central venous access devices as assessed by the ability to withdraw blood.
How does alteplase work?
alteplase binds to the fibrin-plasminogen complex in a blood clot and converts the inactive plasminogen into active plasmin which digests the fibrin. ACTIVASE can dissolve a clot in either the coronary or pulmonary artery, restoring the blood supply to the area beyond the blockage.
How do I take alteplase?
alteplase is typically dosed as follows:
- Patients weighing ≥30 kg: 2 mg in 2 mL
- Patients weighing < 30 kg: 110% of the internal lumen volume of the catheter, not to exceed 2 mg in 2 mL
- If catheter function is not restored at 120 minutes after 1 dose of alteplase, a second dose may be instilled
Is it safe for me to take alteplase?
alteplase is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following.
- Active internal bleeding
- Recent intracranial or intraspinal surgery or serious head trauma
- Intracranial conditions that may increase the risk of bleeding
- Bleeding diathesis
- Current severe uncontrolled hypertension
- Current intracranial hemorrhage
- History of recent stroke
alteplase Common Side Effects
Common side effects of alteplase:
- Bleeding
alteplase Serious Side Effects
Serious side effects are rare with alteplase. Contact your healthcare provider immediately if you experience any of the following.
- Severe bleeding
- Swelling
Effects of other drugs, drug classes and over-the-counter products on alteplase
The following medications may interact with alteplase:
- Anticoagulants and drugs that inhibit platelet function increase the risk of bleeding when administered with ACTIVASE therapy
- Concomitant angiotensin-converting enzyme inhibitors may increase the risk of orolingual angioedema
Who makes alteplase?
Various FDA-approved generic manufacturers
Is alteplase safe in pregnancy?
alteplase may harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with alteplase.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
Drug Savings Tips
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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