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Manufactured by Genentech, Inc.

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

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CATHFLO ACTIVASE Uses, Side Effects, Interactions, Warnings & Dosing



CATHFLO ACTIVASE is the brand name for alteplase that is injected into a dysfunctional catheter.

What dosages is CATHFLO ACTIVASE available in?

What dosages is CATHFLO ACTIVASE available in?

CATHFLO ACTIVASE is available in in vials that contains 2.2 mg of alteplase.

What is CATHFLO ACTIVASE used for?

What is CATHFLO ACTIVASE used for?

CATHFLO ACTIVASE is a tissue plasminogen activator (tPA) indicated for the restoration of function to central venous access devices as assessed by the ability to withdraw blood.



CATHFLO ACTIVASE binds to the fibrin-plasminogen complex in a blood clot and converts the inactive plasminogen into active plasmin which digests the fibrin. ACTIVASE can dissolve a clot in either the coronary or pulmonary artery, restoring the blood supply to the area beyond the blockage.



CATHFLO ACTIVASE is typically dosed as follows:

  • Patients weighing ≥30 kg: 2 mg in 2 mL
  • Patients weighing < 30 kg: 110% of the internal lumen volume of the catheter, not to exceed 2 mg in 2 mL
  • If catheter function is not restored at 120 minutes after 1 dose of CATHFLO ACTIVASE, a second dose may be instilled
Is it safe for me to take CATHFLO ACTIVASE?

Is it safe for me to take CATHFLO ACTIVASE?

CATHFLO ACTIVASE is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following.

  • Active internal bleeding
  • Recent intracranial or intraspinal surgery or serious head trauma
  • Intracranial conditions that may increase the risk of bleeding
  • Bleeding diathesis
  • Current severe uncontrolled hypertension
  • Current intracranial hemorrhage
  • History of recent stroke
CATHFLO ACTIVASE Common Side Effects

CATHFLO ACTIVASE Common Side Effects

Common side effects of CATHFLO ACTIVASE:

  • Bleeding
CATHFLO ACTIVASE Serious Side Effects

CATHFLO ACTIVASE Serious Side Effects

Serious side effects are rare with CATHFLO ACTIVASE. Contact your healthcare provider immediately if you experience any of the following.

  • Severe bleeding
  • Swelling
Effects of other drugs, drug classes and over-the-counter products on CATHFLO ACTIVASE

Effects of other drugs, drug classes and over-the-counter products on CATHFLO ACTIVASE

The following medications may interact with CATHFLO ACTIVASE:

  • Anticoagulants and drugs that inhibit platelet function increase the risk of bleeding when administered with ACTIVASE therapy
  • Concomitant angiotensin-converting enzyme inhibitors may increase the risk of orolingual angioedema


Genentech, Inc.

Is CATHFLO ACTIVASE safe in pregnancy?

Is CATHFLO ACTIVASE safe in pregnancy?

CATHFLO ACTIVASE may harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with CATHFLO ACTIVASE.


What to do if you missed your CATHFLO ACTIVASE dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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