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Cathflo Activase is the brand name for alteplase that is injected into a dysfunctional catheter.

Cathflo Activase is available in in vials that contains 2.2 mg of alteplase.

Cathflo Activase is a tissue plasminogen activator (tPA) indicated for the restoration of function to central venous access devices as assessed by the ability to withdraw blood.

Cathflo Activase binds to the fibrin-plasminogen complex in a blood clot and converts the inactive plasminogen into active plasmin which digests the fibrin. ACTIVASE can dissolve a clot in either the coronary or pulmonary artery, restoring the blood supply to the area beyond the blockage.

Cathflo Activase is typically dosed as follows:

• Patients weighing ≥30 kg: 2 mg in 2 mL
• Patients weighing < 30 kg: 110% of the internal lumen volume of the catheter, not to exceed 2 mg in 2 mL
• If catheter function is not restored at 120 minutes after 1 dose of Cathflo Activase, a second dose may be instilled

Cathflo Activase is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following.

• Active internal bleeding
• Recent intracranial or intraspinal surgery or serious head trauma
• Intracranial conditions that may increase the risk of bleeding
• Bleeding diathesis
• Current severe uncontrolled hypertension
• Current intracranial hemorrhage
• History of recent stroke

Common side effects of Cathflo Activase:

• Bleeding

Serious side effects are rare with Cathflo Activase. Contact your healthcare provider immediately if you experience any of the following.

• Severe bleeding
• Swelling

The following medications may interact with Cathflo Activase:

• Anticoagulants and drugs that inhibit platelet function increase the risk of bleeding when administered with ACTIVASE therapy
• Concomitant angiotensin-converting enzyme inhibitors may increase the risk of orolingual angioedema

Genentech, Inc.

Cathflo Activase may harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with Cathflo Activase.

• Alteplase