ZYTIGA
Used for Cancer
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Manufactured by Janssen Pharmaceuticals
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ZYTIGA Uses, Side Effects, Interactions, Warnings & Dosing
What is ZYTIGA?
ZYTIGA is the brand name for abiraterone and is available as an oral tablet.
What dosages is ZYTIGA available in?
ZYTIGA is available as 250 mg and 500 mg oral tablet.
What is ZYTIGA used for?
ZYTIGA is a CYP17 inhibitor indicated in combination with prednisone for the treatment of patients with:
- metastatic castration-resistant prostate cancer (CRPC)
- metastatic high-risk castration-sensitive prostate cancer (CSPC)
How does ZYTIGA work?
ZYTIGA works by interrupting the androgen-making process at an important step. It inhibits androgen at 3 sources—the testes, the adrenal glands, AND the tumor itself.
How do I take ZYTIGA?
ZYTIGA is typically taken for:
Metastatic castration-resistant prostate cancer:
- ZYTIGA 1,000 mg orally once daily with prednisone 5 mg orally twice daily
Metastatic castration-sensitive prostate cancer:
- ZYTIGA 1,000 mg orally once daily with prednisone 5 mg orally once daily
- Patients receiving ZYTIGA should also receive a gonadotropin-releasing
- hormone (GnRH) analog concurrently or should have had bilateral orchiectomy
- ZYTIGA tablets must be taken as a single dose once daily on an empty stomach
- Do not eat food 2 hours before and 1 hour after taking ZYTIGA. The tablets must be swallowed whole with water. Do not crush or chew tablets
Is it safe for me to take ZYTIGA?
ZYTIGA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
ZYTIGA Common Side Effects
Common side effects of ZYTIGA:
- Fatigue
- Arthralgia
- Hypertension
- Nausea
- Edema
- Hypokalemia
- Hot flush
- Diarrhea
- Vomiting
- Upper respiratory infection
- Cough
- Headache
ZYTIGA Serious Side Effects
Serious side effects are rare with ZYTIGA. Some examples include:
- High blood pressure (hypertension), low blood potassium levels (hypokalemia), fluid retention (edema), and irregular heartbeats
- Adrenal problems
- Severe liver problems
- Liver problems.
- Low blood sugar
- Increased risk of bone fracture and death
Effects of other drugs, drug classes and over-the-counter products on ZYTIGA
The following medications may interact with ZYTIGA:
- CYP3A4 Inducers: Avoid concomitant strong CYP3A4 inducers during ZYTIGA treatment. If a strong CYP3A4 inducer must be co-administered, increase the ZYTIGA dosing frequency CYP2D6 Substrates: Avoid co-administration of ZYTIGA with CYP2D6 substrates that have a narrow therapeutic index. If an alternative treatment cannot be used, exercise caution and consider a dose reduction of the concomitant CYP2D6 substrate
Who makes ZYTIGA?
Janssen Pharmaceuticals
Is ZYTIGA safe in pregnancy?
The safety and efficacy of ZYTIGA have not been established in females. Based on findings from animal studies and the mechanism of action, ZYTIGA can cause fetal harm and potential loss of pregnancy.
What is the generic name for ZYTIGA?
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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