abiraterone acetate

abiraterone acetate

Used for Cancer

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Manufactured by various FDA-approved generic manufacturers.

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Updated on 24 Apr 2024

abiraterone acetate Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is abiraterone acetate available in?

What dosages is abiraterone acetate available in?

abiraterone acetate is available as 250 mg and 500 mg oral tablet.

What is abiraterone acetate used for?

What is abiraterone acetate used for?

abiraterone acetate is a CYP17 inhibitor indicated in combination with prednisone for the treatment of patients with:

  • metastatic castration-resistant prostate cancer (CRPC)
  • metastatic high-risk castration-sensitive prostate cancer (CSPC)
How does abiraterone acetate work?

How does abiraterone acetate work?

abiraterone acetate works by interrupting the androgen-making process at an important step. It inhibits androgen at 3 sources—the testes, the adrenal glands, AND the tumor itself.

How do I take abiraterone acetate?

How do I take abiraterone acetate?

abiraterone acetate is typically taken for:

Metastatic castration-resistant prostate cancer:

  • abiraterone acetate 1,000 mg orally once daily with prednisone 5 mg orally twice daily

Metastatic castration-sensitive prostate cancer:

  • abiraterone acetate 1,000 mg orally once daily with prednisone 5 mg orally once daily
  • Patients receiving abiraterone acetate should also receive a gonadotropin-releasing
  • hormone (GnRH) analog concurrently or should have had bilateral orchiectomy
  • abiraterone acetate tablets must be taken as a single dose once daily on an empty stomach
  • Do not eat food 2 hours before and 1 hour after taking abiraterone acetate. The tablets must be swallowed whole with water. Do not crush or chew tablets
Is it safe for me to take abiraterone acetate?

Is it safe for me to take abiraterone acetate?

abiraterone acetate is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

abiraterone acetate Common Side Effects

abiraterone acetate Common Side Effects

Common side effects of abiraterone acetate:

  • Fatigue
  • Arthralgia
  • Hypertension
  • Nausea
  • Edema
  • Hypokalemia
  • Hot flush
  • Diarrhea
  • Vomiting
  • Upper respiratory infection
  • Cough
  • Headache
abiraterone acetate Serious Side Effects

abiraterone acetate Serious Side Effects

Serious side effects are rare with abiraterone acetate. Some examples include:

  • High blood pressure (hypertension), low blood potassium levels (hypokalemia), fluid retention (edema), and irregular heartbeats
  • Adrenal problems
  • Severe liver problems
  • Liver problems.
  • Low blood sugar
  • Increased risk of bone fracture and death
Effects of other drugs, drug classes and over-the-counter products on abiraterone acetate

Effects of other drugs, drug classes and over-the-counter products on abiraterone acetate

The following medications may interact with abiraterone acetate:

  • CYP3A4 Inducers: Avoid concomitant strong CYP3A4 inducers during abiraterone acetate treatment. If a strong CYP3A4 inducer must be co-administered, increase the abiraterone acetate dosing frequency CYP2D6 Substrates: Avoid co-administration of abiraterone acetate with CYP2D6 substrates that have a narrow therapeutic index. If an alternative treatment cannot be used, exercise caution and consider a dose reduction of the concomitant CYP2D6 substrate
Who makes abiraterone acetate?

Who makes abiraterone acetate?

Various FDA-approved generic manufacturers

Is abiraterone acetate safe in pregnancy?

Is abiraterone acetate safe in pregnancy?

The safety and efficacy of abiraterone acetate have not been established in females. Based on findings from animal studies and the mechanism of action, abiraterone acetate can cause fetal harm and potential loss of pregnancy.


What to do if you missed your abiraterone acetate dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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