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Zykadia is the brand name for ceritinib and is available as an oral capsule and tablet.

Zykadia is available as a 150 mg oral capsule and tablet.

Zykadia is a kinase inhibitor that is used to treat anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) that has spread to other areas of the body.

Zykadia is a kinase inhibitor. It blocks the activity of a specific protein called anaplastic lymphoma kinase (ALK). The ALK protein, which is found in both normal and cancer cells, signals cells to grow. Cancer cells sometimes have more ALK than normal cells. This can cause cancer cells to grow more quickly than normal cells. Zykadia works to block ALK, so cancer cells can’t grow and spread as well.

The typical starting dose of Zykadia is 450 mg taken by mouth once a day. Your dose might be different if you have severe liver problems.

Zykadia is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Zykadia:

• Abnormal liver labs
• Diarrhea
• Low red blood cell levels
• Nausea
• Abnormal kidney labs
• Vomiting
• Stomach pain
• Higher blood sugar levels
• Tiredness
• Lower phosphate levels
• Abnormal pancreas labs
• Loss of appetite

Serious side effects are rare with Zykadia. Contact your healthcare provider immediately if you experience any of the following.

• Serious heart rhythm problems: blurry vision, feeling light-headed, weakness, pounding heart
• Lung problems: cough, fever, trouble breathing, shortness of breath, chest pain
• Pancreas problems: upper stomach or back that gets worse when you eat, unexplained weight loss, nausea, or vomiting
• Liver problems: nausea, vomiting stomach pain or swelling, itchy skin, dark-colored urine, pale-colored stool, yellowing of the whites of the eyes or skin
• Severe stomach problems: diarrhea, nausea, vomiting, or stomach pain

The following medications may interact with Zykadia:

• CYP3A Inhibitors and Inducers: Avoid concurrent use of Zykadia with strong CYP3A inhibitors or inducers. If concurrent use of a strong CYP3A inhibitor is unavoidable, dose reduce Zykadia
• CYP3A Substrates: Avoid coadministration of Zykadia with sensitive CYP3A substrates
• CYP2C9 Substrates: Avoid coadministration of Zykadia with CYP2C9 substrates for which minimal concentration changes may lead to serious toxicities

Novartis Pharmaceuticals

Zykadia can harm your unborn baby. Females who are able to become pregnant should use an effective method of birth control during treatment with Zykadia and for 6 months after stopping Zykadia. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think that you may be pregnant. Males with female partners who are able to become pregnant should use condoms during treatment with
Zykadia and for 3 months after stopping Zykadia.

• Ceritinib