Used for Cancer

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Updated on 24 Apr 2024

ceritinib Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is ceritinib available in?

What dosages is ceritinib available in?

ceritinib is available as a 150 mg oral capsule and tablet.

What is ceritinib used for?

What is ceritinib used for?

ceritinib is a kinase inhibitor that is used to treat anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) that has spread to other areas of the body.

How does ceritinib work?

How does ceritinib work?

ceritinib is a kinase inhibitor. It blocks the activity of a specific protein called anaplastic lymphoma kinase (ALK). The ALK protein, which is found in both normal and cancer cells, signals cells to grow. Cancer cells sometimes have more ALK than normal cells. This can cause cancer cells to grow more quickly than normal cells. ceritinib works to block ALK, so cancer cells can’t grow and spread as well.

How do I take ceritinib?

How do I take ceritinib?

The typical starting dose of ceritinib is 450 mg taken by mouth once a day. Your dose might be different if you have severe liver problems.

Is it safe for me to take ceritinib?

Is it safe for me to take ceritinib?

ceritinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

ceritinib Common Side Effects

ceritinib Common Side Effects

Common side effects of ceritinib:

  • Abnormal liver labs
  • Diarrhea
  • Low red blood cell levels
  • Nausea
  • Abnormal kidney labs
  • Vomiting
  • Stomach pain
  • Higher blood sugar levels
  • Tiredness
  • Lower phosphate levels
  • Abnormal pancreas labs
  • Loss of appetite
ceritinib Serious Side Effects

ceritinib Serious Side Effects

Serious side effects are rare with ceritinib. Contact your healthcare provider immediately if you experience any of the following.

  • Serious heart rhythm problems: blurry vision, feeling light-headed, weakness, pounding heart
  • Lung problems: cough, fever, trouble breathing, shortness of breath, chest pain
  • Pancreas problems: upper stomach or back that gets worse when you eat, unexplained weight loss, nausea, or vomiting
  • Liver problems: nausea, vomiting stomach pain or swelling, itchy skin, dark-colored urine, pale-colored stool, yellowing of the whites of the eyes or skin
  • Severe stomach problems: diarrhea, nausea, vomiting, or stomach pain
Effects of other drugs, drug classes and over-the-counter products on ceritinib

Effects of other drugs, drug classes and over-the-counter products on ceritinib

The following medications may interact with ceritinib:

  • CYP3A Inhibitors and Inducers: Avoid concurrent use of ceritinib with strong CYP3A inhibitors or inducers. If concurrent use of a strong CYP3A inhibitor is unavoidable, dose reduce ceritinib
  • CYP3A Substrates: Avoid coadministration of ceritinib with sensitive CYP3A substrates
  • CYP2C9 Substrates: Avoid coadministration of ceritinib with CYP2C9 substrates for which minimal concentration changes may lead to serious toxicities
Who makes ceritinib?

Who makes ceritinib?

Various FDA-approved generic manufacturers

Is ceritinib safe in pregnancy?

Is ceritinib safe in pregnancy?

ceritinib can harm your unborn baby. Females who are able to become pregnant should use an effective method of birth control during treatment with ceritinib and for 6 months after stopping ceritinib. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think that you may be pregnant. Males with female partners who are able to become pregnant should use condoms during treatment with
ceritinib and for 3 months after stopping ceritinib.


What to do if you missed your ceritinib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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