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Zyclara is the brand name for imiquimod and is available as a topical cream.

Zyclara is available as a topical cream in strengths of 2.5% and 3.75%.

Zyclara is a topical skin product and is used for the following:
Face or scalp actinic keratosis (scaly precancerous spot or growth on the skin) in adults – all brands and strengths
Genital and anal warts in adults and children 12 years and older – Zyclara 3.75% and Aldara 5% only Superficial basal cell carcinoma (a type of skin cancer) in adults – Aldara 5% only

Zyclara is a topical skin product. It’s not exactly clear how the medication works, but it activates the immune system to fight off certain types of cancer, warts, and skin damage.

Zyclara is dosed as follows:

Actinic keratosis (adults)

• Zyclara 2.5% and 3.75%: Apply up to 0.5 grams (2 packets or 2 pumps) to the affected area once daily for 2 weeks. Afterwards, stop using the medication for 2 weeks, then use it again
• Aldara 5%: Apply to the affected area 2 times per week (for example, Monday and Thursday, or Tuesday and Friday) for 16 weeks. Use no more than one packet of Aldara per dose
• Genital and anal warts in (adults and children 12 years and older)
• Zyclara 3.75%: Apply up to 0.25 grams (1 packet or 1 pump) to the wart once daily until the wart is totally gone, for no more than 8 weeks
• ldara 5%: Apply to the wart 3 times per week (for example, Monday/Wednesday/Friday or Tuesday/Thursday/Saturday) until the wart is totally gone, for no more than 16 weeks.

Superficial basal cell carcinoma (adults)

• Aldara 5%: Apply to the affected area 5 times per week (for example, Monday through Friday) for 6 weeks. Your provider will tell you the right amount to use depending on the size of the tumor

Zyclara is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Zyclara:

• Skin reaction, including itching, burning, bleeding, stinging, and pain
• Common cold symptoms
• Sinus inflammation
• Headache

Serious side effects are rare with Zyclara. Contact your healthcare provider immediately if you experience any of the following.

• Severe skin reactions
• Difficulty urinating due to genital swelling

There are no major drug interactions listed for Zyclara. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Bausch Health

It is not known if Zyclara Cream can harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant.

• Imiquimod