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Zavzpret is the brand name for zavegepant and is available as a nasal spray.

Zavzpret is available as a 10 mg nasal spray.

Zavzpret is a CGRP receptor blocker that is used to treat migraine attacks with or without aura in adults.

Zavzpret is a calcitonin gene-related peptide (CGRP) receptor blocker. High levels of a substance in our bodies called CGRP cause pain and inflammation, which commonly leads to migraines. Zavzpret blocks CGRP, which is thought to prevent pain and inflammation, leading to migraine relief.

Each Zavzpret spray contains 10 mg of zavegepant.

The typical dose is 1 spray (10 mg) in one nostril as needed for when you have a migraine attack. The maximum dose is 1 spray in a 24-hour period.

Zavzpret is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Zavzpret:

• Changes in taste or loss of taste
• Nausea
• Discomfort in the nose
• Vomiting

Serious side effects are rare with Zavzpret. Contact your healthcare provider immediately if you experience any of the following.

Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing

The following medications may interact with Zavzpret:

• Avoid use with drugs that inhibit OATP1B3 or NTCP transporters.
• Avoid use with drugs that induce OATP1B3 or NTCP transporters.
• Avoid use of intranasal decongestants; if unavoidable, administer
• intranasal decongestants at least 1 hour after Zavzpret
• administration.

Pfizer

It is not known if Zavzpret can harm your unborn baby. Tell your healthcare provider right away if you become pregnant while taking Zavzpret. You and your healthcare provider will decide if you should take Zavzpret while you are pregnant.

• Zavegepant