Used for Depression

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Manufactured by GlaxoSmithKline

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Updated on 26 Apr 2024

WELLBUTRIN XL Uses, Side Effects, Interactions, Warnings & Dosing



WELLBUTRIN XL is the brand name for bupropion and is available as an extended-release oral tablet.

What dosages is WELLBUTRIN XL available in?

What dosages is WELLBUTRIN XL available in?

WELLBUTRIN XL is available as a 150 mg and 300 mg extended-release oral tablet.

What is WELLBUTRIN XL used for?

What is WELLBUTRIN XL used for?

WELLBUTRIN XL is an atypical antidepressant that is used to treat:
Seasonal affective disorder (SAD) – only bupropion HCl extended-release (Wellbutrin XL)

How does WELLBUTRIN XL work?

How does WELLBUTRIN XL work?

WELLBUTRIN XL is an atypical antidepressant. It’s not fully known how the medication works but it’s thought to boost norepinephrine and dopamine levels in the brain, which can help to improve mood and depression.

How do I take WELLBUTRIN XL?

How do I take WELLBUTRIN XL?

WELLBUTRIN XL is typically started at 150 mg by mouth once daily in the morning. After 4 days, your provider might raise your dose to 300 mg once daily.

Is it safe for me to take WELLBUTRIN XL?

Is it safe for me to take WELLBUTRIN XL?

WELLBUTRIN XL is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:
History of seizures
History of eating disorders (e.g., bulimia or anorexia)
Stopping alcohol, benzodiazepines, barbiturates, antiepileptic medications suddenly
Take, have recently taken (within the last 14 days), or plan to take (within the next 14 days) medications called monoamine oxidase inhibitors (MAOIs), such as rasagiline (Azilect) or selegiline (Eldepryl)
Treatment with linezolid or intravenous methylene blue

WELLBUTRIN XL Common Side Effects

WELLBUTRIN XL Common Side Effects

  • Common side effects of WELLBUTRIN XL:
  • Headache
  • Dry mouth
  • Nausea
  • Trouble sleeping
  • Dizziness
  • Sore throat
  • Constipation
  • Restlessness (agitation)
  • Stomach pain
  • Anxiety
WELLBUTRIN XL Serious Side Effects

WELLBUTRIN XL Serious Side Effects

Serious side effects are rare with WELLBUTRIN XL. Contact your healthcare provider immediately if you experience any of the following.
Suicidal thoughts and changes in mood or behavior
Serious allergic reactions: itchy skin, skin rash, hives, swelling, shortness of breath, chest pain
Severe skin reactions: painful rash, fluid-filled blisters, fever, sore throat, peeling skin
Manic episodes: very high or low energy, angry or very happy, problems with sleep
Vision problems: eye pain, changes in vision, swelling or redness in or around the eye

Effects of other drugs, drug classes and over-the-counter products on WELLBUTRIN XL

Effects of other drugs, drug classes and over-the-counter products on WELLBUTRIN XL

The following medications may interact with WELLBUTRIN XL:

  • CYP2B6 inducers: Dose increase may be necessary if coadministered
  • with CYP2B6 inducers (e.g., ritonavir, lopinavir, efavirenz
  • carbamazepine, phenobarbital, and phenytoin) based on clinical response
  • but should not exceed the maximum recommended dose.
  • Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can
  • increase concentrations of: antidepressants (e.g., venlafaxine
  • nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline)
  • antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers
  • (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone
  • flecainide). Consider dose reduction when using with bupropion.
  • Digoxin: May decrease plasma digoxin levels. Monitor digoxin levels.
  • Drugs that lower seizure threshold: Dose WELLBUTRIN XL with
  • caution.
  • Dopaminergic drugs (levodopa and amantadine): CNS toxicity can occur
  • when used concomitantly with WELLBUTRIN XL.
  • MAOIs: Increased risk of hypertensive reactions can occur when used
  • concomitantly with WELLBUTRIN XL.
  • Drug-laboratory test interactions: WELLBUTRIN XL can cause falsepositive urine test results for amphetamines.



Is WELLBUTRIN XL safe in pregnancy?

Is WELLBUTRIN XL safe in pregnancy?

It is not known if WELLBUTRIN XL will harm your
unborn baby. You and your doctor will have to decide if you should take WELLBUTRIN XL while you are pregnant or if you plan to become pregnant. There is an independent pregnancy exposure registry that monitors pregnancy outcomes in
women exposed to any antidepressants during pregnancy. Healthcare providers are encouraged
to register patients by calling the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at MGH Center for womens mental health.


What to do if you missed your WELLBUTRIN XL dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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