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Wainua is the brand name for eplontersen and is available as a subcutaneous injection.

Wainua is available as 45 mg/0.8 mL single-dose autoinjector.

Wainua is a medication used to treat polyneuropathy from hereditary transthyretin-mediated amyloidosis (hATTR).

Wainua is an antisense therapeutic. It works by breaking down mutated versions of the TTR gene in the body. This lessens the amount of abnormal TTR proteins made, which lessens the amount of amyloid fibrils that can cause damage to the body.

The recommended dose of Wainua is 45 mg via subcutaneous injection once monthly into the abdomen or upper thigh region. The back if the upper arm can be used if a healthcare provider or caregiver gives the injection.

Wainua is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Wainua:

• Drop in vitamin A levels
• Vomiting
• High amount of protein in the urine
• Injection site reactions

Serious side effects are rare with Wainua. Contact your healthcare provider immediately if you experience any of the following:

• Serious vision problems

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

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It is not known whether this medication is safe for you and your unborn baby during pregnancy. Changes in vitamin A levels and vitamin A supplementation related to use of Wainua may harm your unborn baby. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Eplontersen