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Vyloy is the brand name for zolbetuximab-clzb and is available as an intravenous infusion.

Vyloy is available as a 100 mg and 300 mg single-dose vial.

Vyloy is a prescription medicine used to treat adults with advanced stomach cancer (gastric adenocarcinoma) or gastroesophageal junction (GEJ) cancer.

Vyloy is a monoclonal antibody that targets the Claudin 18.2 (CLDN18.2) protein, which is found on the surface of certain cancer cells. Once Vyloy attaches to the CLDN18.2 protein, it flags the cancer cells for the immune system to destroy them.

The recommended first dose of Vyloy is 800 mg/m2 followed by 600 mg/m2 every 3 weeks or 400 mg/m2 every 2 weeks via IV infusion.

Vyloy is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Vyloy:

• Nausea and vomiting (sometimes severe)
• Decreased appetite
• Diarrhea
• Stomach pain
• Fatigue
• Fever
• Headache
• Weight loss
• Constipation

Serious side effects are rare with Vyloy. Contact your healthcare provider immediately if you experience any of the following:

• Hypersensitivity reactions including serious anaphylaxis reactions

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

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It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Zolbetuximab-Clzb