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Vumerity is the brand name for diroximel fumarate and is available as a delayed-release capsule.

Vumerity is available as a 231 mg delayed-release capsule.

Vumerity is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Vumerity is a type of disease-modifying therapy (DMT) called a fumaric acid derivative. More specifically, Vumerity (diroximel fumarate) is a Nrf2 activator. It’s not exactly known how Vumerity helps with multiple sclerosis. But the medication is thought to turn on Nrf2 pathways in the body to help protect against damage to nerve cells and lessen inflammation.

Vumerity is dosed as follows:

• Starting dose: 231 mg twice a day, by mouth, for 7 days
• Maintenance dose after 7 days: 462 mg (administered as two 231 mg
• Capsules) by mouth twice a day

Vumerity is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Known hypersensitivity to diroximel fumarate, dimethyl fumarate, or to any of the excipients in the product
• Co-administration with dimethyl fumarate

Common side effects of Vumerity:

• Flushing
• Stomach pain
• Diarrhea
• Nausea

Serious side effects are rare with Vumerity. Contact your healthcare provider immediately if you experience any of the following:Severe allergic reaction: hives, rash, red skin, swelling of the lips or tongue, closing of the throat, difficulty breathing
Severe infection: fever, difficulty breathing, diarrhea, weakness, vision problems, thinking or memory problems, personality changes
Serious liver problems: pain on the right side of your stomach, yellowing of your skin or the whites of your eyes (jaundice), loss of appetite, dark urine
Serious Stomach or gut issues: severe stomach pain; severe vomiting, constipation, or diarrhea; rectal bleeding; bloody diarrhea

The following medications may interact with Vumerity:

• Dimethyl fumarate

Biogen, Inc.

Based on animal data, Vumerity may cause fetal harm. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Diroximel Fumarate