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Diroximel Fumarate is available as a 231 mg delayed-release capsule.

Diroximel Fumarate is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Diroximel Fumarate is a type of disease-modifying therapy (DMT) called a fumaric acid derivative. More specifically, Diroximel Fumarate is a Nrf2 activator. It’s not exactly known how Diroximel Fumarate helps with multiple sclerosis. But the medication is thought to turn on Nrf2 pathways in the body to help protect against damage to nerve cells and lessen inflammation.

Diroximel Fumarate is dosed as follows:

• Starting dose: 231 mg twice a day, by mouth, for 7 days
• Maintenance dose after 7 days: 462 mg (administered as two 231 mg
• Capsules) by mouth twice a day

Diroximel Fumarate is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Known hypersensitivity to Diroximel Fumarate, dimethyl fumarate, or to any of the excipients in the product
• Co-administration with dimethyl fumarate

Common side effects of Diroximel Fumarate:

• Flushing
• Stomach pain
• Diarrhea
• Nausea

Serious side effects are rare with Diroximel Fumarate. Contact your healthcare provider immediately if you experience any of the following:Severe allergic reaction: hives, rash, red skin, swelling of the lips or tongue, closing of the throat, difficulty breathing
Severe infection: fever, difficulty breathing, diarrhea, weakness, vision problems, thinking or memory problems, personality changes
Serious liver problems: pain on the right side of your stomach, yellowing of your skin or the whites of your eyes (jaundice), loss of appetite, dark urine
Serious Stomach or gut issues: severe stomach pain; severe vomiting, constipation, or diarrhea; rectal bleeding; bloody diarrhea

The following medications may interact with Diroximel Fumarate:

• Dimethyl fumarate

Various FDA-approved generic manufacturers

Based on animal data, Diroximel Fumarate may cause fetal harm. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Vumerity