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Veletri is the brand name for epoprostenol and is available as an injection for IV use.

Veletri is available as a 0.5 mg (500,000 ng) or 1.5 mg
(1,500,000 ng) injection for IV use.

Veletri is a prostacyclin vasodilator and is used to treat pulmonary arterial hypertension (PAH).

Veletri is a prostacyclin vasodilator. Prostacyclins work by relaxing muscles in the arteries (blood vessels), which leads to vasodilation. Vasodilation means that the blood vessels widen, which allows more blood to flow through them. In addition, prostacyclins prevent platelets, pieces of cells found in the blood, from sticking to each other. This also helps improve blood flow. PAH occurs when blood can’t flow freely through the arteries in your lungs. This raises the blood pressure in your lungs, causing your heart to have to work harder to send blood to your lungs for oxygen. Veletri helps with PAH because it improves the blood flow in your arteries.

Veletri is an intravenous (IV) infusion that’s given through a pump programmed to deliver your dose over a certain period of time. Before starting Veletri, your provider will typically insert a catheter into a large vein near the heart. Your care team will train you on how to use the pump at home. Your provider will calculate the dose based on your body weight. The typical starting dose is 2 nanograms (ng) per kg of body weight per minute (2 ng/kg/min). The dose can be adjusted by your provider based on your response to the medication.

Veletri is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:

• Congestive heart failure due to severe left ventricular systolic dysfunction
• Pulmonary edema
• Hypersensitivity to the drug or to structurally related compounds

Common side effects of Veletri:

• Flushing
• Headache
• Nausea/vomiting
• Low blood pressure
• Anxiety, nervousness, or agitation
• Chest pain

Serious side effects are rare with Veletri. Contact your healthcare provider immediately if you experience any of the following.

• Excess fluid in the lungs: shortness of breath, cough, chest pain, fatigue
• Bleeding problems: unusual or easy bleeding or bruising, vomiting or coughing up blood, blood in your urine or stool

The following medications may interact with Veletri:

• Diuretics, antihypertensive agents, or other vasodilators: reduction in blood pressure
• Antiplatelet agents or anticoagulants: increase the risk of bleeding
• Patients on digoxin: elevations of digoxin concentrations clinically significant in patients prone to digoxin toxicity

Janssen Pharmaceuticals

It is not known if Veletri will harm your unborn baby. Veletri should be used during pregnancy only if the potential benefit justifies the potential risk to fetus.

• Epoprostenol