Used for Hypertension

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Manufactured by Janssen Pharmaceuticals

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

VELETRI Uses, Side Effects, Interactions, Warnings & Dosing

What is VELETRI?

What is VELETRI?

VELETRI is the brand name for epoprostenol and is available as an injection for IV use.

What dosages is VELETRI available in?

What dosages is VELETRI available in?

VELETRI is available as a 0.5 mg (500,000 ng) or 1.5 mg
(1,500,000 ng) injection for IV use.

What is VELETRI used for?

What is VELETRI used for?

VELETRI is a prostacyclin vasodilator and is used to treat pulmonary arterial hypertension (PAH).

How does VELETRI work?

How does VELETRI work?

VELETRI is a prostacyclin vasodilator. Prostacyclins work by relaxing muscles in the arteries (blood vessels), which leads to vasodilation. Vasodilation means that the blood vessels widen, which allows more blood to flow through them. In addition, prostacyclins prevent platelets, pieces of cells found in the blood, from sticking to each other. This also helps improve blood flow. PAH occurs when blood can’t flow freely through the arteries in your lungs. This raises the blood pressure in your lungs, causing your heart to have to work harder to send blood to your lungs for oxygen. VELETRI helps with PAH because it improves the blood flow in your arteries.

How do I take VELETRI?

How do I take VELETRI?

VELETRI is an intravenous (IV) infusion that’s given through a pump programmed to deliver your dose over a certain period of time. Before starting VELETRI, your provider will typically insert a catheter into a large vein near the heart. Your care team will train you on how to use the pump at home. Your provider will calculate the dose based on your body weight. The typical starting dose is 2 nanograms (ng) per kg of body weight per minute (2 ng/kg/min). The dose can be adjusted by your provider based on your response to the medication.

Is it safe for me to take VELETRI?

Is it safe for me to take VELETRI?

VELETRI is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:

  • Congestive heart failure due to severe left ventricular systolic dysfunction
  • Pulmonary edema
  • Hypersensitivity to the drug or to structurally related compounds
VELETRI Common Side Effects

VELETRI Common Side Effects

Common side effects of VELETRI:

  • Flushing
  • Headache
  • Nausea/vomiting
  • Low blood pressure
  • Anxiety, nervousness, or agitation
  • Chest pain
VELETRI Serious Side Effects

VELETRI Serious Side Effects

Serious side effects are rare with VELETRI. Contact your healthcare provider immediately if you experience any of the following.

  • Excess fluid in the lungs: shortness of breath, cough, chest pain, fatigue
  • Bleeding problems: unusual or easy bleeding or bruising, vomiting or coughing up blood, blood in your urine or stool
Effects of other drugs, drug classes and over-the-counter products on VELETRI

Effects of other drugs, drug classes and over-the-counter products on VELETRI

The following medications may interact with VELETRI:

  • Diuretics, antihypertensive agents, or other vasodilators: reduction in blood pressure
  • Antiplatelet agents or anticoagulants: increase the risk of bleeding
  • Patients on digoxin: elevations of digoxin concentrations clinically significant in patients prone to digoxin toxicity
Who makes VELETRI?

Who makes VELETRI?

Janssen Pharmaceuticals

Is VELETRI safe in pregnancy?

Is VELETRI safe in pregnancy?

It is not known if VELETRI will harm your unborn baby. VELETRI should be used during pregnancy only if the potential benefit justifies the potential risk to fetus.


What to do if you missed your VELETRI dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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