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Umeclidinium/Vilanterol is available as an inhalation powder that contains 62.5 mcg umeclidinium and 25 mcg vilanterol
(62.5/25 mcg) per actuation.

Umeclidinium/Vilanterol is a LAMA / LABA combo and is used to treat chronic obstructive pulmonary disease (COPD).

Umeclidinium/Vilanterol is a combination medication used for COPD. It contains umeclidinium and vilanterol. Umeclidinium is a long-acting muscarinic antagonist (LAMA) that relaxes the muscles around the airways in the lungs to help you breathe easier. Vilanterol is a long-acting beta-agonist (LABA) that helps open up your airways in the lungs for easier breathing.

Umeclidinium/Vilanterol is typically taken as 1 puff or inhalation by mouth once daily.

Umeclidinium/Vilanterol is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a severe hypersensitivity to milk proteins or any ingredients. Also, the use of a LABA, including Umeclidinium/Vilanterol, without an inhaled corticosteroid is contraindicated in patients with asthma.

Common side effects of Umeclidinium/Vilanterol:

• Swelling of the throat
• Swelling of the sinuses
• Lower respiratory tract infection (viral infection in the lungs)
• Constipation
• Diarrhea
• Pain in hands or feet
• Muscle spasms
• Neck pain
• Chest pain

Serious side effects are rare with Umeclidinium/Vilanterol. Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reactions: trouble breathing, hives, swelling of your face, lips, tongue, or throat

The following medications may interact with Umeclidinium/Vilanterol:

• Strong cytochrome P450 3A4 inhibitors (e.g., ketoconazole): Use with caution. May cause cardiovascular effects
• Monoamine oxidase inhibitors and tricyclic antidepressants: Use with extreme caution. May potentiate effect of vilanterol on cardiovascular
• system
• Beta-blockers: Use with caution. May block bronchodilatory effects of beta-agonists and produce severe bronchospasm
• Diuretics: Use with caution. Electrocardiographic changes and/or hypokalemia associated with non–potassium-sparing diuretics may worsen with concomitant beta-agonists
• Anticholinergics: May interact additively with concomitantly used anticholinergic medications. Avoid administration of Umeclidinium/Vilanterol with other anticholinergic-containing drugs

Various FDA-approved generic manufacturers

It is not known if Umeclidinium/Vilanterol may harm your unborn baby. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Anoro Ellipta