TREXALL
Used for Cancer
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Manufactured by Teva Pharmaceuticals
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TREXALL Uses, Side Effects, Interactions, Warnings & Dosing
What is TREXALL?
TREXALL is the brand name for methotrexate and is available as an oral tablet.
What dosages is TREXALL available in?
TREXALL is available as a 2.5 mg oral tablet.
What is TREXALL used for?
TREXALL is an antimetabolite that is used to treat:
Acute lymphoblastic leukemia (ALL) in adults and children; given with other chemotherapy Cutaneous T-cell lymphoma in adults; given by itself or with other chemotherapy Advanced non-Hodgkin lymphoma in adults; given with other chemotherapy Rheumatoid arthritis (RA) in adults
Polyarticular juvenile idiopathic arthritis (pJIA) in children Severe psoriasis in adults
How does TREXALL work?
TREXALL is an antimetabolite medication that treats many types of cancers and non-cancer conditions (like arthritis and psoriasis). For cancer: TREXALL works by blocking dihydrofolate reductase, a protein in your body that’s important for making DNA in cells and for cell growth. Since cancer cells grow much more quickly than healthy cells, the medication helps slow down cancer growth so the cancer can’t spread as well.
For non-cancer conditions: We don’t know exactly how TREXALL works to treat non-cancer conditions such as rheumatoid arthritis and psoriasis. But research suggests that, at lower doses, it blocks the immune system from becoming too active. For psoriasis, the medication might also help slow down the growth of skin cells.
How do I take TREXALL?
The dose of TREXALL varies depending on what condition you’re taking the medication for. Sometimes, the dose depends on your body size or body surface area (BSA) in m2 units. It is typically taken by mouth up to 4 times a week.
Is it safe for me to take TREXALL?
TREXALL is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are pregnant or breastfeeding, have alcoholic liver disease, bone marrow hypoplasia, leukopenia, thrombocytopenia or
significant anemia.
TREXALL Common Side Effects
Common side effects of TREXALL:
- Mouth sores
- Nausea or vomiting
- Diarrhea
- Stomach upset
- Dizziness
- Tiredness
- Chills
- Fever
- Infection
- Higher liver enzyme levels in the blood
- Low white blood cells
- Low platelet levels
TREXALL Serious Side Effects
Serious side effects are rare with TREXALL. Contact your healthcare provider immediately if you experience any of the following.
- Serious infections (from having low white blood cell counts): temperature of 100.4 degrees Fahrenheit, with or without other symptoms, such as chills, cough, muscle aches, very fast heartbeat, confusion
Low platelets: blood in urine or stool, nosebleeds, unexplained bruising or bleeding, bruising or bleeding that doesn’t go away - Serious lung problems: sudden cough, fever, difficulty breathing
- Serious liver problems: nausea, vomiting, tiredness, stomach pain or swelling, pale-colored stool, dark-colored urine, yellowing of the whites of the eyes or skin
Serious nervous system problems: headache, confusion, vision changes, difficulty talking, difficulty moving one side of the body, seizure, coma - Serious skin reactions: painful blisters, skin wounds, peeling skin, fever, sore throat, body aches
Allergic reaction: rash, difficulty breathing, swelling of the mouth or around the eyes
Effects of other drugs, drug classes and over-the-counter products on TREXALL
The following medications may interact with TREXALL:
- Concomitant administration of some NSAIDs with high dose TREXALL therapy has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and gastrointestinal toxicity
- TREXALL is partially bound to serum albumin, and toxicity may be increased because of displacement by certain drugs, such as salicylates, phenylbutazone phenytoin, and sulfonamides. Renal tubular transport is also diminished by probenecid; use of TREXALL with this drug should be carefully monitored
- Oral antibiotics such as tetracycline, chloramphenicol, and nonabsorbable broad spectrum antibiotics, may decrease intestinal absorption of TREXALL or interfere with the enterohepatic circulation by inhibiting bowel flora and suppressing metabolism of the drug by bacteria
- Penicillins may reduce the renal clearance of TREXALL; increased serum concentrations of TREXALL with concomitant hematologic and gastrointestinal
- toxicity have been observed with TREXALL. Use of TREXALL with penicillins should be carefully monitored
Who makes TREXALL?
Teva Pharmaceuticals
Is TREXALL safe in pregnancy?
TREXALL can cause embryo-fetal toxicity, including fetal death. For non-neoplastic diseases, TREXALL is contraindicated in pregnancy. For neoplastic diseases, advise patients of reproductive potential of the potential risk to a fetus and to use effective contraception.
What to do if you missed your TREXALL dose
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
What is the drug Trexall used for?
Is methotrexate a nasty drug?
How long does Trexall take to work?
What are side effects of Trexall?
What damage does methotrexate do to your body?
Why is methotrexate so toxic?
Is Trexall the same as methotrexate?
Can Trexall cause liver damage?
Why is methotrexate banned?
What are common side effects of Trexall?
Is there a better drug than methotrexate?
Is Trexall safe?
What is the generic name of Trexall?
How damaging is methotrexate?
How often should methotrexate Trexall for RA be administered orally?
Is methotrexate banned?
What are the long term side effects of methotrexate?
How much does Trexall cost?
What is the side effect of Trexall?
How long does Trexall stay in your system?
How long does it take for Trexall to work?
What is generic for Trexall?
Can you drink alcohol while taking Trexall?
Why are they banning methotrexate?
What is the warning for Trexall?
Are methotrexate injections covered by insurance?
Is methotrexate worth the risk?
How is Trexall administered?
When should I take Trexall?
Can you get methotrexate over the counter?
What is methotrexate used to treat?
Is methotrexate a form of chemo?
Does methotrexate make you gain weight?
How long should you stay on methotrexate?
What to avoid when taking methotrexate?
Is methotrexate a high risk medication?
Who Cannot take methotrexate?
How painful is methotrexate treatment?
Does methotrexate cause hair loss?
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