MethotrexatePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Methotrexate
    Generic for Trexall, Rheumatrex
    30 tablets $6 USD
    Save $80.40
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Do you need a prescription for methotrexate?

Yes, methotrexate is only available with a valid physician Rx.

How much is methotrexate without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase methotrexate, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for methotrexate in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a methotrexate savings card?

Yes. Save up to 90% on your methotrexate with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a methotrexate coupon provider in the US?

No. Now Patient does not provide methotrexate coupons or FREE methotrexate samples.

Do you accept commercial, Medicare or Medicaid coverage for methotrexate in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much methotrexate?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using methotrexate. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much methotrexate. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic methotrexate?

Generic methotrexate refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of methotrexate

Methotrexate is approved by the U.S. Food and Drug Administration (FDA) for the treatment of various conditions, including rheumatoid arthritis, psoriasis, and certain types of cancer.

Active ingredient of methotrexate

The active ingredient of methotrexate is methotrexate.

US brand name of methotrexate and manufacturer

Methotrexate is available in the US under various brand names, including Rheumatrex and Trexall. It is manufactured by different pharmaceutical companies.

UK brand name of methotrexate and manufacturer

In the UK, methotrexate is available under various brand names, including Maxtrex. The manufacturer may vary depending on the brand name.

Prescription requirement for methotrexate

A prescription (Rx) is required for methotrexate in both the US and the UK.

Availability of methotrexate in the UK with NHS prescription

Methotrexate is available in the UK with an NHS prescription.

Conditions treated by methotrexate

Methotrexate is used to treat a range of conditions, including rheumatoid arthritis, psoriasis, psoriatic arthritis, certain types of cancer (such as leukemia and lymphoma), and ectopic pregnancy.

How does methotrexate work?

Methotrexate is an immunosuppressive medication that works by inhibiting the metabolism of certain cells, including rapidly dividing cells such as cancer cells or cells involved in inflammation. It helps to reduce inflammation and suppress the immune system’s response, providing relief for conditions such as rheumatoid arthritis and psoriasis.

Forms of methotrexate available

Methotrexate is available in various forms, including oral tablets, injectable solutions, and prefilled syringes for subcutaneous administration.

Dosage of methotrexate

The dosage of methotrexate may vary depending on the specific condition being treated and individual factors. It is important to follow the recommended dosage instructions provided by the healthcare provider.

Directions for methotrexate use

Methotrexate should be taken exactly as directed by the healthcare provider. The medication is typically taken once a week for certain conditions. It may be taken orally or administered by injection, depending on the form prescribed.

Warnings and precautions for methotrexate

  • Methotrexate can have serious side effects, including liver toxicity, lung problems, and bone marrow suppression. Regular monitoring of blood counts and liver function is necessary during treatment
  • Tell your doctor if yoiu have liver disease, lung disease (such as pulmonary fibrosis), suppressed immune system, blood cell/bone marrow disorders, peptic ulcer, ulcerative colitis, or any active infections before taking methotrexate
  • It may interact with certain medications and should be used with caution in individuals with certain medical conditions, such as kidney or liver disease. Inform the healthcare provider about all medications being taken and medical history

Use of methotrexate during pregnancy

Methotrexate is contraindicated during pregnancy as it can cause harm to the developing fetus. Effective contraception should be used during methotrexate treatment, and pregnancy should be avoided.

Use of methotrexate while breastfeeding

Methotrexate is generally not recommended while breastfeeding as it can pass into breast milk and may harm the nursing infant. Breastfeeding should be avoided during methotrexate treatment.

Interactions with other drugs

Methotrexate may have drug interactions with certain medications, including live vaccines, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, sulfasalazine, penicillins, phenytoin, and probenecid. It is important to inform your healthcare provider about all medications, over-the-counter supplements, and herbal products you are taking to avoid potential interactions.

Possible side effects of methotrexate

Common side effects of methotrexate may include nausea, vomiting, drowsiness, mouth sores, sore throat, fatigue, and hair loss. Call a healthcare professional right away if you experience a dry cough, fever, shortness of breath, extreme tiredness, loss of appetite, or yellowing of the skin or eyes. Your doctor will most likely give you folic acid tablets to reduce adverse effects caused by your weekly dose of methotrexate.

Similar drugs to methotrexate

Other medications used for the treatment of conditions such as rheumatoid arthritis and psoriasis include leflunomide, sulfasalazine, and biologic therapies such as adalimumab and etanercept.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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