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Tolcapone is available as a 100 mg oral tablet.

Tolcapone is a COMT inhibitor and is used to treat parkinson’s disease (PD); as add-on treatment to carbidopa/levodopa.

Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor. It blocks the activity of the protein, COMT, which results in more stable levels of levodopa.

The starting dose is 100 mg by mouth three times a day.

Tolcapone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have liver disease, a history of nontraumatic
rhabdomyolysis or hyperpyrexia and confusion possibly related to medication.

Common side effects of Tolcapone:

• Involuntary movements
• Nausea
• Sleep problems
• Excessive dreaming
• Muscle contractions and cramps
• Loss of appetite
• Sleepiness
• Low blood pressure
• Diarrhea
• Dizziness
• Confusion
• Headache

Serious side effects are rare with Tolcapone. Contact your healthcare provider immediately if you experience any of the following.

• Serious liver damage: yellowing of the skin or eyes, pale colored stools, loss of appetite, persistent nausea, tiredness, low energy, dark urine, itchiness, tenderness in the upper right side of your stomach
• Severe muscle damage (rhabdomyolysis): muscle aches, soreness, cramping, dark-colored urine
• Symptoms similar to neuroleptic malignant syndrome (NMS): very high fevers, irregular pulse, sweating, muscle stiffness, confusion, changes in blood pressure

The following medications may interact with Tolcapone:

• Drugs Metabolized by Catechol-O-Methyltransferase (COMT): Tolcapone may influence the pharmacokinetics of drugs metabolized by COMT. A dose reduction of such compounds should be considered when they are co-administered with Tolcapone.
• Due to its affinity to cytochrome P450 2C9 in vitro, Tolcapone may interfere with drugs whose clearance is dependent on this metabolic pathway, such as tolbutamide and warfarin

Various FDA-approved generic manufacturers

There is no experience from clinical studies regarding the use of Tolcapone in pregnant women. Therefore, Tolcapone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Tasmar