tolcapone
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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You can lower cost of your tolcapone using one of the 4 following drug savings programs
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tolcapone Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is tolcapone available in?
tolcapone is available as a 100 mg oral tablet.
What is tolcapone used for?
tolcapone is a COMT inhibitor and is used to treat parkinson’s disease (PD); as add-on treatment to carbidopa/levodopa.
How does tolcapone work?
tolcapone is a catechol-O-methyltransferase (COMT) inhibitor. It blocks the activity of the protein, COMT, which results in more stable levels of levodopa.
How do I take tolcapone?
The starting dose is 100 mg by mouth three times a day.
Is it safe for me to take tolcapone?
tolcapone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have liver disease, a history of nontraumatic
rhabdomyolysis or hyperpyrexia and confusion possibly related to medication.
tolcapone Common Side Effects
Common side effects of tolcapone:
- Involuntary movements
- Nausea
- Sleep problems
- Excessive dreaming
- Muscle contractions and cramps
- Loss of appetite
- Sleepiness
- Low blood pressure
- Diarrhea
- Dizziness
- Confusion
- Headache
tolcapone Serious Side Effects
Serious side effects are rare with tolcapone. Contact your healthcare provider immediately if you experience any of the following.
- Serious liver damage: yellowing of the skin or eyes, pale colored stools, loss of appetite, persistent nausea, tiredness, low energy, dark urine, itchiness, tenderness in the upper right side of your stomach
- Severe muscle damage (rhabdomyolysis): muscle aches, soreness, cramping, dark-colored urine
- Symptoms similar to neuroleptic malignant syndrome (NMS): very high fevers, irregular pulse, sweating, muscle stiffness, confusion, changes in blood pressure
Effects of other drugs, drug classes and over-the-counter products on tolcapone
The following medications may interact with tolcapone:
- Drugs Metabolized by Catechol-O-Methyltransferase (COMT): tolcapone may influence the pharmacokinetics of drugs metabolized by COMT. A dose reduction of such compounds should be considered when they are co-administered with tolcapone.
- Due to its affinity to cytochrome P450 2C9 in vitro, tolcapone may interfere with drugs whose clearance is dependent on this metabolic pathway, such as tolbutamide and warfarin
Who makes tolcapone?
Various FDA-approved generic manufacturers
Is tolcapone safe in pregnancy?
There is no experience from clinical studies regarding the use of tolcapone in pregnant women. Therefore, tolcapone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
Drug Savings Tips
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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