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Tasmar is the brand name for tolcapone and is available as an oral tablet.

Tasmar is available as a 100 mg oral tablet.

Tasmar is a COMT inhibitor and is used to treat parkinson’s disease (PD); as add-on treatment to carbidopa/levodopa.

Tasmar is a catechol-O-methyltransferase (COMT) inhibitor. It blocks the activity of the protein, COMT, which results in more stable levels of levodopa.

The starting dose is 100 mg by mouth three times a day.

Tasmar is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have liver disease, a history of nontraumatic
rhabdomyolysis or hyperpyrexia and confusion possibly related to medication.

Common side effects of Tasmar:

• Involuntary movements
• Nausea
• Sleep problems
• Excessive dreaming
• Muscle contractions and cramps
• Loss of appetite
• Sleepiness
• Low blood pressure
• Diarrhea
• Dizziness
• Confusion
• Headache

Serious side effects are rare with Tasmar. Contact your healthcare provider immediately if you experience any of the following.

• Serious liver damage: yellowing of the skin or eyes, pale colored stools, loss of appetite, persistent nausea, tiredness, low energy, dark urine, itchiness, tenderness in the upper right side of your stomach
• Severe muscle damage (rhabdomyolysis): muscle aches, soreness, cramping, dark-colored urine
• Symptoms similar to neuroleptic malignant syndrome (NMS): very high fevers, irregular pulse, sweating, muscle stiffness, confusion, changes in blood pressure

The following medications may interact with Tasmar:

• Drugs Metabolized by Catechol-O-Methyltransferase (COMT): Tasmar may influence the pharmacokinetics of drugs metabolized by COMT. A dose reduction of such compounds should be considered when they are co-administered with Tasmar.
• Due to its affinity to cytochrome P450 2C9 in vitro, Tasmar may interfere with drugs whose clearance is dependent on this metabolic pathway, such as tolbutamide and warfarin

Valeant Pharmaceuticals

There is no experience from clinical studies regarding the use of Tasmar in pregnant women. Therefore, Tasmar should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Tolcapone