Used for Depression

Are you tired of high medication costs? Our service offers unbeatable savings on your TOFRANIL prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.

Manufactured by Mallinckrodt Inc.

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

This content is intended for US audiences only

TOFRANIL cost saving options available to you

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    Canadian Prescription Savings

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    Drug Coupons

    Obtain your TOFRANIL for as little as $0 per fill. Suitable for insured individuals only.
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    Patient Assistance Programs

    Obtain your TOFRANIL at no cost. Suitable for insured, underinsured and uninsured individuals

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TOFRANIL Uses, Side Effects, Interactions, Warnings & Dosing



TOFRANIL is the brand name for imipramine and is available as an oral capsule.

What dosages is TOFRANIL available in?

What dosages is TOFRANIL available in?

TOFRANIL is available as a 25 mg and 50 mg oral capsule.

What is TOFRANIL used for?

What is TOFRANIL used for?

TOFRANIL is a tricyclic antidepressant that is used to treat:

  • Depression
  • Bedwetting in children (imipramine hydrochloride only)
How does TOFRANIL work?

How does TOFRANIL work?

TOFRANIL is a tricyclic antidepressant (TCA). The exact way it works isn’t known. For depression, TOFRANIL is thought to work by raising the levels of serotonin and norepinephrine chemicals in your brain; these chemicals are involved with regulating mood. For bedwetting, the medication is thought to allow the bladder to hold more urine.

How do I take TOFRANIL?

How do I take TOFRANIL?

The total daily dose of TOFRANIL is either split up into several smaller doses throughout the day or taken as a single dose before bedtime. Your provider will adjust your dosage based on how well it’s helping your symptoms and whether you’re having side effects.

Is it safe for me to take TOFRANIL?

Is it safe for me to take TOFRANIL?

TOFRANIL is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. The concomitant use of monoamine oxidase inhibiting compounds is contraindicated. Hyperpyretic crises or severe convulsive
seizures may occur in patients receiving such combinations. The potentiation of adverse effects can be serious, or even fatal. When it is desired to substitute Imipramine Hydrochloride Tablets USP in patients receiving a monoamine oxidase inhibitor, as long an page 2 of 10 interval should elapse as the clinical situation will allow, with a minimum of 14 days. Initial dosage should be low and increases should be gradual and cautiously prescribed. The drug is contraindicated during the acute recovery period after a myocardial infarction. Patients with a known hypersensitivity to this compound should not be given the drug. The possibility of cross-sensitivity to other dibenzazepine compounds should be kept in mind.

TOFRANIL Common Side Effects

TOFRANIL Common Side Effects

Common side effects of TOFRANIL:

  • Dry mouth
  • Blurry vision
  • Nausea
  • Vomiting
  • Constipation
  • Sleepiness
  • Dizziness
  • Confusion
  • Anxiety
  • Restlessness
TOFRANIL Serious Side Effects

TOFRANIL Serious Side Effects

Serious side effects are rare with TOFRANIL. Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts or behaviors
  • Heart attack: chest pain, cold sweats, left arm pain, trouble breathing
  • Stroke: sudden numbness, weakness, confusion, trouble talking
  • Serious allergic reaction: difficulty breathing, hives, itching, fast heartbeat, tightness in the throat, dizziness,
  • swelling in the face or tongue
Effects of other drugs, drug classes and over-the-counter products on TOFRANIL

Effects of other drugs, drug classes and over-the-counter products on TOFRANIL

The following medications may interact with TOFRANIL:

  • Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from co-therapy, an increased dose of tricyclic antidepressant may be required
Who makes TOFRANIL?

Who makes TOFRANIL?

Mallinckrodt Inc.

Is TOFRANIL safe in pregnancy?

Is TOFRANIL safe in pregnancy?

There have been no well-controlled studies conducted with pregnant women to determine the effect of TOFRANIL on the fetus. TOFRANIL should be used in women who are or might become pregnant only if the clinical condition clearly justifies potential risk to the fetus.


What to do if you missed your TOFRANIL dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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