Imipramine Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Imipramine HCl
    Generic for Tofranil
    30 tablets $4.2 USD
    Save $17.70
  3. Imipramine HCl
    Generic for Tofranil
    30 tablets $4.2 USD
    Save $17.70
  4. Imipramine HCl
    Generic for Tofranil
    30 tablets $4.5 USD
    Save $17.40
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Do you need a prescription for imipramine?

Yes, imipramine is only available with a valid physician Rx.

How much is imipramine without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase imipramine, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for imipramine in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a imipramine savings card?

Yes. Save up to 90% on your imipramine with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a imipramine coupon provider in the US?

No. Now Patient does not provide imipramine coupons or FREE imipramine samples.

Do you accept commercial, Medicare or Medicaid coverage for imipramine in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much imipramine?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using imipramine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much imipramine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic imipramine?

Generic imipramine refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of imipramine

Imipramine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of depression.

Active ingredient of imipramine

The active ingredient of imipramine is imipramine hydrochloride.

US brand name of imipramine and manufacturer

Imipramine is available in the US under the brand name Tofranil. It is manufactured by various pharmaceutical companies.

UK brand name of imipramine and manufacturer

In the UK, imipramine is available under the brand name imipramine. The manufacturer may vary depending on the brand name.

Prescription requirement for imipramine

A prescription (Rx) is required for imipramine in both the US and the UK.

Availability of imipramine in the UK with NHS prescription

Imipramine is available in the UK with an NHS prescription.

Conditions treated by imipramine

Imipramine is an anticholinergic primarily used for the treatment of depression. It may also be used to treat bed-wetting (enuresis) in children.

How does imipramine work?

Imipramine belongs to a class of medications known as tricyclic antidepressants. It works by increasing the levels of certain neurotransmitters, such as norepinephrine and serotonin, in the brain. This helps to improve mood and alleviate symptoms of depression.

Forms of imipramine available

Imipramine is available in the form of oral tablets.

Dosage of imipramine

The dosage of imipramine may vary depending on the individual’s condition, age, and response to the medication. It is important to follow the recommended dosage instructions provided by the healthcare provider.

Directions for imipramine use

Imipramine should be taken exactly as directed by the healthcare provider. The medication is usually taken orally, with or without food. It is important to take imipramine consistently and continue the prescribed treatment course.

Warnings and precautions for imipramine

  • Imipramine may cause certain side effects, including drowsiness, dizziness, dry mouth, and constipation. It may also increase the risk of suicidal thoughts or behavior, particularly in children and young adults. Close monitoring is necessary during treatment
  • It may interact with certain medications, including monoamine oxidase inhibitors (MAOIs) and other antidepressants. Inform the healthcare provider about all medications being taken
  • Tell your doctor if you have asthma, chronic bronchitis, glaucoma, heart problems such as coronary artery disease, heart disease or heart attacks, liver problems, mental health conditions such as bipolar disorder, or hyperthyroidism

Use of imipramine during pregnancy

The use of imipramine during pregnancy should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider. The medication may be used during pregnancy if the potential benefits outweigh the risks.

Use of imipramine while breastfeeding

Imipramine passes into breast milk. The use of imipramine while breastfeeding should be discussed with a healthcare provider, considering the potential risks and benefits for the mother and the infant.

Possible side effects of imipramine

Common side effects of imipramine may include drowsiness, dry mouth, blurred vision, eye pain, and constipation. Serious side effects are possible but less common. Promptly report any concerning symptoms to a healthcare provider. Get emergency help if you have a life threatening allergic reaction. Symptoms may include trouble breathing, shortness of breath, hives, blisters, skin rash, swelling of your face, tongue or throat.

Interactions with other drugs

Interactions with certain medications may occur when using imipramine. These may include monoamine oxidase inhibitors such as linezolid, methylene blue, and tranylcypromine, clonidine, phenytoin, anticoagulants such as warfarin, cimetidine, medication for high blood pressure, methylphenidate, quinidine, sedatives, selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, paroxetine, and sertraline, St. John’s wort, and thyroid medications. It is important to inform your healthcare provider about all the prescription drugs and over-the-counter supplements you are taking to avoid potential adverse effects and drug interactions.

Similar drugs to imipramine

Other tricyclic antidepressants used for the treatment of depression include amitriptyline, nortriptyline, and desipramine.


  • FDA Prescribing Information for Imipramine
  • MHRA product information for Imipramine
  • WebMD – Imipramine
  • Drugs.com – Imipramine
  • NHS UK
Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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