Key facts about Thymoglobulin
What is Thymoglobulin?
Thymoglobulin is the brand name for anti-thymocyte globulin and is available as an intravenous infusion.
What dosages is Thymoglobulin available in?
Thymoglobulin is available as a single-dose 10 mL vial containing 25 mg of anti-thymocyte globulin (rabbit).
What is Thymoglobulin used for?
Thymoglobulin is an immunoglobulin G indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant.
How does Thymoglobulin work?
Thymoglobulin suppresses the immune system to prevent the body from rejecting a transplanted organ. It does this by targeting and depleting specific white blood cells, particularly T-lymphocytes, which are responsible for identifying and attacking the new organ
How do I take Thymoglobulin?
The dose of Thymoglobulin is based on your weight and white blood cell count. The first dose should be infused over at least 6 hours; doses on subsequent days should be infused over at least 4 hours. (2.2) Premedication with corticosteroids, acetaminophen, and/or an antihistamine prior to each infusion is recommended.
Is it safe for me to take Thymoglobulin?
Thymoglobulin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Allergy or anaphylactic reaction to rabbit proteins or to any product excipients
- Active acute or chronic infections
Thymoglobulin Common Side Effects
Common side effects of Thymoglobulin:
- Urinary tract infection
- Abdominal pain
- Hypertension
- Nausea
- Shortness of breath
- Fever
- Headache
- Anxiety
- Chills
- Increased potassium levels
- Low counts of platelets and
- White blood cells
Thymoglobulin Serious Side Effects
Serious side effects are rare with Thymoglobulin. Contact your healthcare provider immediately if you experience any of the following:
- Allergic reaction
- Increased risk of cancer
- Serious infections
Effects of other drugs, drug classes and over-the-counter products on Thymoglobulin
There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Who makes Thymoglobulin?
Sanofi-Aventis U.S.
Is Thymoglobulin safe in pregnancy?
There is a lack of information on the risks associated with the use of Thymoglobulin during pregnancy. Therefore, effective contraception is recommended during and for a minimum of 3 months after treatment.
