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Anti-Thymocyte Globulin is available as a single-dose 10 mL vial containing 25 mg of Anti-Thymocyte Globulin (rabbit).

Anti-Thymocyte Globulin is an immunoglobulin G indicated for the prophylaxis and treatment of acute rejection in patients receiving a kidney transplant.

Anti-Thymocyte Globulin suppresses the immune system to prevent the body from rejecting a transplanted organ. It does this by targeting and depleting specific white blood cells, particularly T-lymphocytes, which are responsible for identifying and attacking the new organ

The dose of Anti-Thymocyte Globulin is based on your weight and white blood cell count. The first dose should be infused over at least 6 hours; doses on subsequent days should be infused over at least 4 hours. (2.2) Premedication with corticosteroids, acetaminophen, and/or an antihistamine prior to each infusion is recommended.

Anti-Thymocyte Globulin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Allergy or anaphylactic reaction to rabbit proteins or to any product excipients
• Active acute or chronic infections

Common side effects of Anti-Thymocyte Globulin:

• Urinary tract infection
• Abdominal pain
• Hypertension
• Nausea
• Shortness of breath
• Fever
• Headache
• Anxiety
• Chills
• Increased potassium levels
• Low counts of platelets and
• White blood cells

Serious side effects are rare with Anti-Thymocyte Globulin. Contact your healthcare provider immediately if you experience any of the following:

• Allergic reaction
• Increased risk of cancer
• Serious infections

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

There is a lack of information on the risks associated with the use of Anti-Thymocyte Globulin during pregnancy. Therefore, effective contraception is recommended during and for a minimum of 3 months after treatment.

• Thymoglobulin