Key facts about Temsirolimus
What dosages is Temsirolimus available in?
Temsirolimus is available in a strength of 25 mg/mL.
What is Temsirolimus used for?
Temsirolimus is a kinase inhibitor indicated for the treatment of advanced renal cell carcinoma.
How does Temsirolimus work?
Temsirolimus is a kinase inhibitor which inhibits the mTOR kinase. A kinase is an enzyme that promotes cell growth. There are many types of kinases, which control different phases of cell growth. By blocking a particular enzyme from working, this medication can slow the growth of cancer cells.
How do I take Temsirolimus?
The recommended dose of Temsirolimus is 25 mg administered as an intravenous infusion over a 30–60 minute period once a week. Treat until disease progression or unacceptable toxicity. Pre-treatment with an antihistamine is recommended.
Is it safe for me to take Temsirolimus?
Temsirolimus is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Patients with bilirubin > 1.5×ULN
Temsirolimus Common Side Effects
Common side effects of Temsirolimus:
- Rash
- Weakness
- Nausea
- Edema
- Weight loss
- Low Red Blood Cell Count (anemia)
- High Blood Sugar (hyperglycemia)
- Increased risk of infection
Temsirolimus Serious Side Effects
Serious side effects are rare with Temsirolimus. Contact your healthcare provider immediately if you experience any of the following:
- Hypersensitivity/infusion reactions
- Liver damage
- Serious lung problems
- Kidney damage
- Bleeding in the brain
Effects of other drugs, drug classes and over-the-counter products on Temsirolimus
The following medications may interact with Temsirolimus:
- Strong inducers of CYP3A4/5 and inhibitors of CYP3A4
Who makes Temsirolimus?
Various FDA-approved generic manufacturers
Is Temsirolimus safe in pregnancy?
Temsirolimus can cause fetal harm when administered to a pregnant woman. Females who can become pregnant should use effective contraception during treatment and for 3 months after the last dose. Males with partners who can become pregnant should use effective contraception during treatment and for 3 months after the last dose.
