Key facts about Talzenna
What is Talzenna?
Talzenna is the brand name for talazoparib and is available as an oral capsule.
What dosages is Talzenna available in?
Talzenna is available as a 0.1 mg, 0.25 mg, 0.35 mg, 0.5 mg, 0.75 mg, and 1 mg oral capsule.
What is Talzenna used for?
Talzenna is a PARP inhibitor that is used to treat:
- Advanced or metastatic HER2-negative breast cancer with certain mutations in the BRCA gene
- Metastatic, castration-resistant prostate cancer with HRR gene mutations; taken with Xtandi (enzalutamide)
How does Talzenna work?
Talzenna is a PARP inhibitor, which means it blocks the PARP protein from working. The PARP protein normally helps cells, including cancer cells, grow and survive by fixing damaged DNA. By blocking PARP from working, Talzenna prevents cancer cells from repairing their DNA, which kills the cancer cells.
How do I take Talzenna?
Your dose of Talzenna depends on your cancer.
- Breast cancer: The typical dose is 1 mg by mouth once a day
- Prostate cancer: The typical dose is 0.5 mg by mouth once a day
Your provider might adjust your Talzenna (talazoparib) dose depending on your kidney function, any side effects you have, and the other medications you’re taking.
Is it safe for me to take Talzenna?
Talzenna is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
Talzenna Common Side Effects
Common side effects of Talzenna:
Talzenna Serious Side Effects
Serious side effects are rare with Talzenna.
Effects of other drugs, drug classes and over-the-counter products on Talzenna
The following medications may interact with Talzenna:
- P-gp Inhibitors: Reduce the dose when coadministered with certain P-gp inhibitors. Monitor for increased adverse reactions
- BCRP Inhibitors: Monitor for potential increased adverse reactions
Who makes Talzenna?
Pfizer Inc.
Is Talzenna safe in pregnancy?
Talzenna can harm your unborn baby, and may cause loss of pregnancy (miscarriage). You should not become pregnant during treatment with Talzenna. Tell your healthcare provider right away if you are pregnant or become pregnant during treatment with Talzenna. If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with Talzenna. Females who are able to become pregnant should use effective birth control (contraception) during treatment with Talzenna and for at least 7 months after receiving the last dose of Talzenna. Talk to your healthcare provider about forms of birth control that may be right for you. Males with female partners who are pregnant or are able to become pregnant should use effective birth control during treatment with Talzenna and for at least 4 months after receiving the last dose of Talzenna.
