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Talazoparib is available as a 0.1 mg, 0.25 mg, 0.35 mg, 0.5 mg, 0.75 mg, and 1 mg oral capsule.

Talazoparib is a PARP inhibitor that is used to treat:

• Advanced or metastatic HER2-negative breast cancer with certain mutations in the BRCA gene
• Metastatic, castration-resistant prostate cancer with HRR gene mutations; taken with Xtandi (enzalutamide)

Talazoparib is a PARP inhibitor, which means it blocks the PARP protein from working. The PARP protein normally helps cells, including cancer cells, grow and survive by fixing damaged DNA. By blocking PARP from working, Talazoparib prevents cancer cells from repairing their DNA, which kills the cancer cells.

Your dose of Talazoparib depends on your cancer.

• Breast cancer: The typical dose is 1 mg by mouth once a day
• Prostate cancer: The typical dose is 0.5 mg by mouth once a day

Your provider might adjust your Talazoparib dose depending on your kidney function, any side effects you have, and the other medications you’re taking.

Talazoparib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Talazoparib:

Serious side effects are rare with Talazoparib.

The following medications may interact with Talazoparib:

• P-gp Inhibitors: Reduce the dose when coadministered with certain P-gp inhibitors. Monitor for increased adverse reactions
• BCRP Inhibitors: Monitor for potential increased adverse reactions

Various FDA-approved generic manufacturers

Talazoparib can harm your unborn baby, and may cause loss of pregnancy (miscarriage). You should not become pregnant during treatment with Talazoparib. Tell your healthcare provider right away if you are pregnant or become pregnant during treatment with Talazoparib. If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with Talazoparib. Females who are able to become pregnant should use effective birth control (contraception) during treatment with Talazoparib and for at least 7 months after receiving the last dose of Talazoparib. Talk to your healthcare provider about forms of birth control that may be right for you. Males with female partners who are pregnant or are able to become pregnant should use effective birth control during treatment with Talazoparib and for at least 4 months after receiving the last dose of Talazoparib.

• Talzenna