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Taliglucerase Alfa is available as a 200 unit IV injection.

Taliglucerase Alfa is a hydrolytic lysosomal glucocerebrosidase-specific enzyme and is used to treat type 1 Gaucher disease in adults and children 4 years of age or older.

Taliglucerase Alfa is a plant-based, modified (lab-made) version of the enzyme glucocerebrosidase that is normally found in the body. People with Gaucher disease don’t have enough of this enzyme, which breaks down a fatty substance called glucocerebroside. As a result, there are higher levels of glucocerebroside in the body, and it can build up in the spleen, liver, and bones. Taliglucerase Alfa works as an enzyme replacement for glucocerebrosidase and helps your body break down glucocerebroside.

Taliglucerase Alfa is an intravenous (IV) infusion that is administered by a healthcare provider. The dose depends on your weight.

• If you haven’t been treated before (treatment naive): In general, the typical starting dose is 60 units/kg once every other week
• If you’re switching from Cerezyme (imiglucerase): The usual starting dose of Taliglucerase Alfa is the same dose of Cerezyme (imiglucerase) you were previously on

Taliglucerase Alfa is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Taliglucerase Alfa:

• Headache
• Joint pain
• Arm or leg pain
• Fatigue
• Nausea
• Dizziness

Serious side effects are rare with Taliglucerase Alfa. Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reactions: throat tightness or irritation, trouble breathing, cough, wheezing, itching or hives, flushing, swelling, chest pain or tightness, dizziness, fainting, nausea, vomiting

There are no major drug interactions listed for Taliglucerase Alfa. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

It is not known if Taliglucerase Alfa can harm your unborn baby. Taliglucerase Alfa should only be used during pregnancy if the benefit to you is worth the possible risk to your baby.

• Elelyso